Abstract
Objective: To evaluate the association between diagnosis of Alzheimer’s Disease (AD) and brain-derived neurotrophic factor (BDNF) gene polymorphisms 196 G/A and 270 C/T. Methods: The authors conducted a meta-analysis along with Trial Sequential Analysis (TSA) of BDNF 196 G/A and 270 C/T polymorphisms and AD in all the available case-control studies on the topic published from 2002 to 2016. Results: Results showed no significant association between BDNF 196 G/A and 270 C/T polymorphisms and AD in overall and ethnicity specific studies. Conclusion: The present comprehensive meta-analysis suggested that further studies focusing on larger sample-size multi-ethnicity studies with homogeneous AD patients and well-matched controls are needed for future study to confirm the results of the study.
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