Abstract
ObjectiveThis study aims to examine the association between inflammatory biomarkers and dyslipidemia and its components among Mongolians in China.MethodsData were obtained from 2544 Mongolians via standard questionnaires and blood samples in Inner Mongolia, China. High sensitivity C-reactive protein (hsCRP), soluble intercellular adhesion molecule-1 (sICAM-1) and soluble E-selectin (sE-selectin) as well as blood lipids were examined.ResultsIndividuals with dyslipidemia had higher levels of hsCRP, sICAM-1 and sE-selectin than those without dyslipidemia (all P values<0.001). Compared to the lowest quartile of inflammatory biomarkers, individuals with the highest quartile were more likely to have dyslipidemia (odds ratio, 95% confidence interval: 3.215, 2.551–4.116 for hsCRP; 1.575, 1.253–1.980 for sICAM-1; 1.495, 1.193–1.873 for sE-selectin). Moreover, hsCRP was associated with all the components of dyslipidemia, whereas, sICAM-1 was not related to high density lipoprotein cholesterol (HDL-c) or triglycerides (TAG). Additionally, sE-selectin was just associated with TAG.ConclusionOur study indicated that elevated plasma levels of hsCRP, sICAM-1 and sE-selectin were positively and significantly associated with increased risk of dyslipidemia among Mongolians. However, the associations were not identical for different inflammatory biomarkers with the components of dyslipidemia.
Highlights
With the remarkable improvement of people’s living standard and associated lifestyle changes in China, dyslipidemia has become more prevalent during the last decades
Among 2589 participants, total 2544 people with complete data were included in this analysis, 1062 subjects (41.75%) of 2544 people were diagnosed as dyslipidemia
In this cross-sectional study among residents of Inner Mongolia, we found that elevated High sensitivity C-reactive protein (hsCRP), soluble intercellular adhesion molecule-1 (sICAM-1) and sE-selectin levels were positively and significantly associated with dyslipidemia
Summary
With the remarkable improvement of people’s living standard and associated lifestyle changes in China, dyslipidemia has become more prevalent during the last decades. Dyslipidemia, characterized by alterations in the concentration of one or more lipoproteins in the blood, including elevated total cholesterol (TC), triglycerides (TAG), low density lipoprotein cholesterol (LDL-c) and HDL-c, is a well-established risk factor for atherosclerosis and cardiovascular disease. Atherosclerosis is widely recognized as a chronic inflammatory vessel disorder and the most important single contributor to the growing burden of cardiovascular disease. Clinical and epidemiological studies across different ethnic groups demonstrated that biomarkers of inflammation were associated with atherosclerosis, leading to myocardial infarction (MI) and stroke [5,6]. To our knowledge, no previous study has examined this association in persons of Mongolian ethnicity.
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call