Association of Autoimmunity and Parvovirus B19 Infection among Spontaneous Miscarriage Women in Erbil / Iraq

Nyan J. Mohammed

doi:10.33899/rjs.2020.164472

Abstract

The study was conducted from January 2016 to January 2017 at Maternity Teaching Hospital in Erbil city/ Iraq. One hundred and forty women who experienced spontaneous abortions were selected according to inclusion and exclusion criteria and forty normal pregnant women as a control group. Serum from patients and control group subjected for assessment of anticardiolipin IgM, antiphospholipid IgM, Parvovirus B19 IgG and IgM using enzyme linked immune-sorbent assay technique. Prevalence of positive Parvovirus B19 IgG and IgM, anticardiolipin IgM and antiphospholipid IgM, in aborted women was higher than that observed in non-aborted women (control group). Women with the highest frequency of spontaneous abortion found at age group 27–34 year. More frequent of previous spontaneous abortion was 1-2 abortion at the 1st trimester of gestational period. Anticardiolipin antibody and antiphospholipid antibody production trigged by viral infection, and have role in spontaneous abortion in pregnant women.

Highlights

Spontaneous abortion means loss of an embryo or fetus before the 24th week of pregnancy
It was reported that antiphospholipid antibodies (APL) and ACL interfere with fetal implantation, which related to the pathological mechanism responsible for recurrent abortions (Clark et al, 2012).Viral
Non-significant differences in the mean values of age, vaccination, child with birth defect and ACL IgM were observed between control and aborted women, while significant difference was found between the groups in number of gestation period and APL IgM

Summary

INTRODUCTION

Spontaneous abortion means loss of an embryo or fetus before the 24th week of pregnancy. The usual way in which the fetus is infected is by transplacental spread after maternal infection in which the organism circulates in the mother's blood. These infections, acquired in utero, can be severe enough to cause fetal loss or can result in intrauterine growth restriction, prematurity, or chronic postnatal infection (Christiansen et al, 2008). It was reported that antiphospholipid antibodies (APL) and ACL interfere with fetal implantation, which related to the pathological mechanism responsible for recurrent abortions (Clark et al, 2012).Viral. The greatest risk to the fetus occurs in the gestational age ranging between weeks 10 and 20, which coincides with the development of erythroid precursors: the virus can infect erythroid precursors inhibiting erythropoiesis and cause a non-immune hydrops (Chisaka et al, 2006)

MATERIALS AND METHODS

RESULTS AND DISCUSSIONS

CONCLUSIONS