Association of ApoB, ApoAIand ApoB/ApoAI ratio with intracranial atherosclerotic stenosis in patients with ischemic stroke

Abstract

Objective To investigate the relationship between apolipoprotein B (ApoB), apolipoprotein AⅠ(ApoAⅠ) and their ratios and intracranial cerebral atherosclerotic stenosis (ICAS) in patients with acute ischemic stroke. Methods The patients with large artery atherosclerotic stroke were enrolled retrospectively. The patients were divided into either an ICAS group or a non-ICAS group based on their vascular imaging data. The blood pressure, blood lipids, blood glucose, ApoB, ApoAⅠ, and ApoB/ApoAⅠ ratios and demographic data were collected. The differences of the above indicators were compared between the two groups. Results A total of 360 patients with large artery atherosclerotic stroke were enrolled. There were 177 patients in the ICAS group (49.2%) and 183 in the non-ICAS group (50.8%). There were significant differences in the constituent ratios of the patients with hypertension, diabetes and coronary heart disease, as well as the levels of low-density lipoprotein cholesterol, ApoB and ApoAⅠ and ApoB/ApoAⅠratios between the 2 groups (all P 1.00 g/L: OR 6.41, 95% CI 2.82-14.49) and ApoB/ApoAⅠ ratio ≥0.60 (0.60-0.73: OR 1.92, 95% CI 1.14-3.24; 0.74-0.91: OR 1.79, 95% CI 1.06-3.02; >0.91: OR 3.30, 95% CI 1.92-5.67) were the independent risk factors for ICAS, while ApoAⅠ>1.28 g/L was an independent protective factor for ICAS (OR 0.39, 95% CI 0.16-0.98; P=0.044). Conclusions The increased ApoB level and ApoB/ApoAⅠ ratio are the independent risk factors for ICAS, and the increased ApoAⅠ level is an independent protective factor for ICAS in patients with acute ischemic stroke. The ApoB/ApoAⅠ ratio can be used as a biomarker of ICAS in patients with ischemic stroke in Chinese population. Key words: Apolipoprotein B; Apolipoprotein AⅠ; Stroke; Brain Ischemia; Intracranial Arteriosclerosis; Biological Markers; Risk Factors