Abstract
The role of Helicobacter pylori (H. pylori) infection in haematological system diseases is not well understood. We conducted this retrospective study to explore the association between H. pylori infection and anaemia in the Chinese population. This retrospective study was performed in Aerospace Center Hospital in Beijing. We derived the data from the registration system of the physical population between 2012–2016. Logistic regression models were used to explore the association between H. pylori infection and anaemia. Among 17,791 subjects, there were 7,804 (43.9%) subjects with H. pylori infection and 950 (5.3%) with anaemia. The prevalence of anaemia in the H. pylori (+) group was significantly higher than in the H. pylori (−) group after adjusting for age, sex, marriage, underlying diseases and body mass index. Compared to H. pylori (−), the OR of H. pylori (+) was 1.39 for moderate-to-severe anaemia and 1.05 for mild anaemia. The level of haemoglobin was lower in the H. pylori (+) group than in the H. pylori (−) group. This study indicates that H. pylori infection may be related to anaemia and haemoglobin level in the Chinese population.
Highlights
Anaemia is a serious public health problem, and its prevalence remains unacceptably high in many regions[1,2,3], affecting roughly a third of the world’s population[4]
As observed in one meta-analysis[1], which included most of the previous studies on anaemia and H. pylori, the past studies were imperfect with notable shortcomings
We conducted this retrospective study using data from the registration system of the physical population to explore the association between H. pylori infection and anaemia in the Chinese population
Summary
Anaemia is a serious public health problem, and its prevalence remains unacceptably high in many regions[1,2,3], affecting roughly a third of the world’s population[4]. Reports from different areas and countries are not consistent regarding this association between anaemia and H. pylori infection[1] and the underlying mechanisms remain unclear. Most previous international researches on H. pylori infection and anaemia was concentrated on women and children, especially pregnant women, rather than the general population, with relatively small sample sizes. No published studies with large sample sizes have explored the association between H. pylori and anaemia in the Chinese adult population. We conducted this retrospective study using data from the registration system of the physical population to explore the association between H. pylori infection and anaemia in the Chinese population
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