Association of Affected Neurocircuitry With Deficit of Response Inhibition and Delayed Gratification in Attention Deficit Hyperactivity Disorder: A Narrative Review.

Xixi Jiang,Haifeng Ji,Yuncheng Zhu,Li Liu

doi:10.3389/fnhum.2018.00506

Abstract

The neural networks that constitute corticostriatothalamocortical circuits between prefrontal cortex and subcortical structure provide a heuristic framework for bridging gaps between neurocircuitry and executive dysfunction in attention deficit hyperactivity disorder (ADHD). “Cool” and “Hot” executive functional theory and the models of dual pathway are supposed to be applied within the neuropsychology of ADHD. The theoretical model elaborated response inhibition and delayed gratification in ADHD. We aimed to review and summarize the literature about the circuits on ADHD and ADHD-related comorbidities, as well as the effects of neurocircuitry on the executive dysfunction in ADHD.

Highlights

The neural networks that constitute corticostriatothalamocortical circuits between prefrontal cortex and subcortical structure provide a heuristic framework for bridging gaps between neurocircuitry and executive dysfunction in attention deficit hyperactivity disorder (ADHD)
We aimed to review and summarize the literature about the circuits on ADHD and ADHD-related comorbidities, as well as the effects of neurocircuitry on the executive dysfunction in ADHD
The neurocircuitries that constitute the CSTC circuit provide a framework for bridging gaps between neuroimaging and Executive function (EF) in ADHD (Zhu et al, 2016), but it has been difficult to identify the mechanisms for regulating abstract thinking and emotional responding from the understanding of ADHD comorbidity with Tourette’s syndrome (TS), oppositional defiant disorder (ODD), and obsessivecompulsive disorder (OCD)

Summary

Introduction

The neural networks that constitute corticostriatothalamocortical circuits between prefrontal cortex and subcortical structure provide a heuristic framework for bridging gaps between neurocircuitry and executive dysfunction in attention deficit hyperactivity disorder (ADHD). The symptoms, such as hyperactivity, impulsivity, compulsivity, irritation or motor tics, may result from similar affected regions of cerebral network. The advanced thoughts built the framework of imaging genetics which is to find associations of neuroimaging as endophenotypes with DNA variants as risky genes, and use hypothesis-free whole-brain voxel-wise genome-wide to associate these studies (Wu et al, 2014).

Objectives

Conclusion