Response inhibition during emotional contexts in children with ADHD: Neural and behavioral data.

Abstract

Event Abstract Back to Event Response inhibition during emotional contexts in children with ADHD: Neural and behavioral data. Sara López-Martín1*, Jacobo Albert2, Alberto Fernández-Jaén3 and Luis Carretié4 1 Universidad Autónoma de Madrid, Psicología Biológica y de la Salud, Spain 2 Universidad Complutense de Madrid, Spain 3 Hospital Quirón, Spain 4 Universidad Autónoma de Madrid, Spain Background: Although the deficit in response inhibition represents one of the most common alterations in attention deficit hyperactivity disorder (ADHD) and increasing evidence points to the presence of emotional problems in patients with this disorder, little is known about the neural and behavioral substrates underlying the interaction of emotion and response inhibition in ADHD. Methods: In an attempt to shed light on this issue, scalp event-related potentials (ERPs) were recorded while 24 children with ADHD and 24 healthy comparison subjects performed a modified version of the Go/Nogo task that required the inhibition of prepotent responses to neutral cues during three different contexts generated by pictorial backgrounds: negative, neutral, and positive. Temporal principal component analyses were employed to detect and quantify, in a reliable manner, those ERP components related to response inhibition (i.e., Nogo-N2 and Nogo-P3), and a source-localization technique (sLORETA) provided information on their neural origin. Results: Behavioral data showed no differences in performance on the emotional Go/Nogo task between ADHD and control groups. Scalp-ERP data revealed that, compared with control subjects, patients with ADHD showed larger frontocentral Nogo-P3 amplitudes and enhanced ventrolateral prefrontal cortex (vlPFC) activation during the successful inhibition of motor responses. These group differences were especially evident during positive (Nogo-P3 amplitude and vlPFC activation) and negative (Nogo-P3 amplitude) contexts. Conclusions: Results suggest that children with ADHD need to activate inhibitory processes more than control subjets to achieve a similar level of performance. The present study provides relevant data data on the neural substrates underlying the interaction of emotion and resposne inhibition in ADHD. Acknowledgements:this work was supported by the grant PSI2011-26314 from the Ministerio de Economía y Economía yCompetitividad of Spain (MINECO) Keywords: EEG, emotion, inhibition, ADHD, ERPs, sLORETA Conference: XII International Conference on Cognitive Neuroscience (ICON-XII), Brisbane, Queensland, Australia, 27 Jul - 31 Jul, 2014. Presentation Type: Poster Topic: Emotional and Social Processes Citation: López-Martín S, Albert J, Fernández-Jaén A and Carretié L (2015). Response inhibition during emotional contexts in children with ADHD: Neural and behavioral data.. Conference Abstract: XII International Conference on Cognitive Neuroscience (ICON-XII). doi: 10.3389/conf.fnhum.2015.217.00219 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 19 Feb 2015; Published Online: 24 Apr 2015. * Correspondence: Mrs. Sara López-Martín, Universidad Autónoma de Madrid, Psicología Biológica y de la Salud, Madrid, Spain, sara.lopez@uam.es Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Sara López-Martín Jacobo Albert Alberto Fernández-Jaén Luis Carretié Google Sara López-Martín Jacobo Albert Alberto Fernández-Jaén Luis Carretié Google Scholar Sara López-Martín Jacobo Albert Alberto Fernández-Jaén Luis Carretié PubMed Sara López-Martín Jacobo Albert Alberto Fernández-Jaén Luis Carretié Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.