Association of Adiposity Indices with Platelet Distribution Width and Mean Platelet Volume in Chinese Adults

Jian Hou,Yuan Liang,Sheng Wei,Meian He,Tian Xu,Handong Yang,Youjie Wang,Weimin Fang,Ping Yao,Tangchun Wu,Jing Yuan,Chuanyao Liu,Xiulou Li,Weihong Chen,Jiang Zhu,Xiaoping Miao,Frank B Hu,Shankuan Zhu

doi:10.1371/journal.pone.0129677

Abstract

Hypoxia is a prominent characteristic of inflammatory tissue lesions. It can affect platelet function. While mean platelet volume (MPV) and platelet distribution width (PDW) are sample platelet indices, they may reflect subcinical platelet activation. To investigated associations between adiposity indices and platelet indices, 17327 eligible individuals (7677 males and 9650 females) from the Dongfeng-Tongji Cohort Study (DFTJ-Cohort Study, n=27009) were included in this study, except for 9682 individuals with missing data on demographical, lifestyle, physical indicators and diseases relative to PDW and MPV. Associations between adiposity indices including waist circumstance (WC), waist-to-height ratio (WHtR), body mass index (BMI), and MPV or PDW in the participants were analyzed using multiple logistic regressions. There were significantly negative associations between abnormal PDW and WC or WHtR for both sexes (p trend<0.001 for all), as well as abnormal MPV and WC or WHtR among female participants (p trend<0.05 for all). In the highest BMI groups, only females with low MPV or PDW were at greater risk for having low MPV (OR=1.33, 95% CI=1.10, 1.62 p trend<0.001) or PDW (OR=1.34, 95% CI=1.14, 1.58, p trend<0.001) than those who had low MPV or PDW in the corresponding lowest BMI group. The change of PDW seems more sensitive than MPV to oxidative stress and hypoxia. Associations between reduced PDW and MPV values and WC, WHtR and BMI values in Chinese female adults may help us to further investigate early changes in human body.

Highlights

Mean platelet volume (MPV) and platelet distribution width (PDW) are quantitative measures of the variability in platelet size
Participants with low MPV or PDW in the highest waist circumstance (WC) group were at a greater risk of having low MPV (odds ratio (OR): 1.09, 95% confidence interval (CI): 0.94, 1.25, ptrend = 0.229) or PDW (OR: 1.90, 95%CI: 1.69, 2.13, ptrend
After adjusting for gender, age, smoking status, passive smoke exposure, drinking status, physical activity, doing housework, hypertension and self-reported hyperlipemia, participants with low MPV or PDW in the highest WC group were at a greater risk of having low MPV (OR: 1.14, 95% CI: 0.98, 1.32, ptrend = 0.069) or PDW (OR: 2.00, 95% CI: 1.77, 2.27, ptrend

Summary

Introduction

Mean platelet volume (MPV) and platelet distribution width (PDW) are quantitative measures of the variability in platelet size. They can be used in the assessment of platelet function [1]. Numerous studies indicated that low PDW and MPV were associated with a range of diseases, including mild cognitive impairment, vascular dementia, Alzheimer’s disease, pulmonary arterial hypertension and osteoporosis [2,3,4,5]. High PDW and MPV were related to acute myocardial infarction, unstable angina and vascular complications of diabetes [6,7,8]. No association was found between coronary artery disease and PDW or MPV, which may be due to the extent of coronary artery disease in response to PDW and MPV levels [11]

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Conclusion