Abstract
Purpose To evaluate platelet parameters in primary open-angle glaucoma (POAG) patients and to explore the association between platelet parameters and POAG severity. Methods A total of 402 consecutive POAG patients and 408 healthy control subjects from the Department of Ophthalmology and Visual Science, Eye and ENT Hospital, Fudan University, were consecutively recruited between January 2016 and October 2018. Detailed ophthalmological and systematic examinations were performed. Blood samples for platelet parameters, including platelet count (PLT), platelet distribution width (PDW), plateletcrit (PCT), mean platelet volume (MPV), and platelet large cell ratio (P-LCR), were analyzed using an automated hematology analyzer in the department of clinical laboratory science of the hospital. The POAG subgroups were classified according to age (<50, ≥50), gender, and visual field mean deviation (MD): mild (MD ≤ 6 dB), moderate (6 dB < MD ≤ 12 dB), and severe (MD > 12 dB). Results In POAG patients, PLT counts (207.08 ± 54.70 ∗ 109/L) were significantly lower (p=0.001) than those of the control group (220.46 ± 55.85 ∗ 109/L). In the POAG group, PDW (13.76 ± 3.16 fL) and MPV (10.46 ± 1.32 fL) values were significantly higher (all p < 0.001) than those of the control group (PDW 11.82 ± 2.44 fL, MPV 10.13 ± 1.10 fL). PDW and MPV values were highest in the severe POAG group (PDW 14.49 ± 2.99 fL; MPV 10.74 ± 1.39 fL), followed by the moderate group (PDW 12.50 ± 3.14 fL; MPV 10.02 ± 1.08 fL) and then the mild group (PDW 11.82 ± 2.44 fL; MPV 9.92 ± 0.76 fL), with statistically significant differences observed between mild-severe POAG and moderate-severe POAG groups by LSD post hoc test. Multiple linear regression analyses showed a significant association between PDW and MD (β = 0.430, p < 0.001) and MPV and MD (β = 0.363, p=0.001). Logistic regression analyses revealed that PDW (OR = 1.297, 95% CI = 1.011–1.663) was associated with the severity of POAG. Conclusions PDW and MPV values were significantly elevated in POAG patients, and PDW was positively associated with disease severity, which suggested the possibility that platelet activation be involved in pathomechanisms of POAG.
Highlights
Glaucoma is a heterogeneous and multifactorial neurodegenerative disease, which is predicted to affect 112 million people worldwide in 2040 [1]
In both the gender and age subgroups, the platelet distribution width (PDW) and mean platelet volume (MPV) levels were significantly higher in the primary open-angle glaucoma (POAG) group in comparison to the control group (Table 2). ere were no significant differences between the two groups regarding PCT and platelet large cell ratio (P-LCR) in all subgroups (p > 0.05). e decreasing changing trend of platelet count (PLT) was similar in all subgroups of POAG patients (p < 0.05) compared to the control group, the change was not statistically significant in female subjects who were younger than 50 (Table 2)
Logistic regression analyses revealed that PDW and BMI were associated with severity of POAG
Summary
Association between Platelet Parameters and Glaucoma Severity in Primary Open-Angle Glaucoma. Yi Ma ,1,2 Jianping Han ,1 Shengjie Li ,1,2 Aiping Zhang ,1 Wenjun Cao ,1,2 and Xinghuai Sun 2,3,4. Received 16 January 2019; Revised 16 April 2019; Accepted 23 April 2019; Published 9 May 2019
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