Association of Added Sugars Intake with Physiologic Parameters in Adults: NHANES 2001–2012

Abstract

The association of added sugars intake with liver enzymes, cardiovascular risk factors, and markers of red cell counts was determined using NHANES 2001–2012 data from adults (19+ years; n=26,402). Dietary intake was determined using 24‐hour dietary recall interviews using an Automated Multiple‐Pass Method. The usual intake of added sugars as a percent of energy was estimated using the Markov Chain Monte Carlo (MCMC) ratio method as implemented in v1.0 of the SAS programs published by the National Cancer Institute (NCI). Balanced repeated replication (BRR) was used for variance estimation. Subjects were separated into six groups: 0<5, 5 to <10, 10 to<15, 15 to <20, 20 to <25, and ≥25% of energy as added sugars. Group trends and linear trends for were determined using linear regression (p<0.01) for: alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, gamma‐glutamyl transferase, lactate dehydrogenase, blood pressure, high‐ and low‐density lipoprotein cholesterol, triglycerides, glucose, c‐reactive protein, waist circumference, ferritin, serum and red blood cell folate, hemoglobin, and hematocrit. None of the liver enzyme levels showed any significant association with added sugars intake. Mean plasma glucose levels (mg/dL) showed an inverse group (beta = −0.71; p=0.0003) and linear trend (beta = −0.13); p=0.0002) association with increasing percent energy of added sugars. No other cardiovascular risk factors, including metabolic syndrome, showed any association with added sugars intake. Only hemoglobin (g/dL) (beta = −0.03, p=0.0007; beta = 0.005, p=0.0013) and hematocrit (%) (beta = −0.09, p=0.0001; beta = −0.02, p=0.0002) showed a group or linear trend, respectively. No other statistical associations were found. These results suggest that the association of usual added sugars intake, as determined by sophisticated models, up to >25% of energy, had limited effect on physiologic parameters in adults.Support or Funding InformationUSDA Hatch Project LAB 94209 and USDA/ARS through specific cooperative agreement 58‐6250‐6‐003 was received. Partial support was also received from the Corn Refiners Association.