Abstract
BackgroundThe association between abdominal fat distribution and metabolic syndrome (MetSyn) components by menopausal status has yet to be explicated. The purpose of this study was to examine a cross-sectional association between abdominal fat compartments and MetSyn components in pre- and post-menopausal overweight Japanese women.MethodsOf 212 overweight Japanese women, 76 pre-menopausal overweight (BMI ≥ 25) women (PreM age, 42.1 ± 5.9 years) and 87 post-menopausal overweight women (PostM: age, 56.2 ± 4.5 years) were analyzed in this study. Measurements were taken for body mass index (BMI), abdominal compartments [visceral fat (VF), subcutaneous fat (SF), superficial subcutaneous fat (SSF), and deep subcutaneous fat (DSF)], serum high-density lipoprotein cholesterol (HDLC), low-density lipoprotein cholesterol, triglycerides (TG), and fasting plasma glucose (FPG). Abdominal compartments were assessed using computed tomography.ResultsNo significant differences were found for BMI, SF, SSF, or DSF between the PreM and PostM. Despite this, the PreM had a significantly smaller VF area than that of the PostM. However, the difference in VF area disappeared when age was adjusted for. VFA significantly correlated with HDLC, TG, and FPG independently of menopause status.ConclusionsThese results suggest that the effect of menopause status on the association between VF and MetSyn components is negligible. Abdominal subcutaneous fat compartments were not associated with MetSyn components in overweight women regardless of menopausal status.
Highlights
The association between abdominal fat distribution and metabolic syndrome (MetSyn) components by menopausal status has yet to be explicated
Whereas total cholesterol (TC), low-density lipoprotein cholesterol (LDLC), and TG were significantly higher in the post-menopausal overweight women (PostM) than in the pre-menopausal overweight women (PreM)
Multiple regression revealed menopause was not an independent predictor of MetSyn components, while VF area (VFA) significantly associated with high-density lipoprotein cholesterol (HDLC), FBG, and TG regardless of menopause status. These results suggest that age rather than menopause status affects the association between abdominal fat compartment and MetSyn components
Summary
The association between abdominal fat distribution and metabolic syndrome (MetSyn) components by menopausal status has yet to be explicated. The purpose of this study was to examine a cross-sectional association between abdominal fat compartments and MetSyn components in pre- and post-menopausal overweight Japanese women. Abdominal obesity is considered a precursor to metabolic syndrome (MetSyn) which is a cluster of risk factors leading to type 2 diabetes or cardiovascular problems [1]. Abdominal subcutaneous fat (SF) contributes to the incidence of MetSyn components [8, 9]. SF is separated into superficial and deep subcutaneous fat (SSF and DSF, respectively) by superficial fascia, a thin layer of connective tissue [10], and these compartments may be associated with metabolic abnormalities. SSF and DSF are important factors in MetSyn
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