Association of ABCA1 (C69T) gene polymorphism with dyslipidemia and type 2 diabetes among the Egyptian population

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ObjectivesTo investigate the possible relationship of ATP-binding cassette transporter A1 (ABCA1) gene polymorphism rs1800977 (C69T) with dyslipidemia and the susceptibility to type 2 diabetes (T2DM) in a cohort of the Egyptian population. MethodsA total of 104 patients with T2DM and 93 healthy controls were recruited in this study. Genotyping of ABCA1 (C69T) single nucleotide polymorphism (SNP) was performed by TaqMan real-time PCR. All genetic models were constructed and the risk of T2DM was determined using multinomial logistic regression analysis and presented as a crude and adjusted odds ratio. The distribution of clinical and biochemical characteristics including body mass index (BMI) and lipid profile was analyzed among different ABCA1 (C69T) genotypes. ResultsABCA1 (C69T) TT genotype and T allele were more frequent in T2DM patients than in healthy controls and associated with significantly higher risk of T2DM compared to the CC genotype (adjusted OR: 5.287, 95%CI: 1.420–18.39, P = .020) and C allele (adjusted OR: 3.121, 95%CI: 1.441–6.756, P = .002). Moreover, the dominant and recessive models of ABCA1 (C69T) SNP were associated with increased T2DM risk. The TT genotype was associated with increased T2DM risk in older patients (≥51 years). The ABCA1 TT genotype was associated with significantly higher BMI, total cholesterol level, and LDL-cholesterol level as well as lower HDL-cholesterol level compared to the CC genotype. The T2DM risk ratios increased after adjustment with lipid profile results in the TT genotype (OR: 8.010, 95%CI: 1.900–33.77, P = .005), CT genotype (OR: 4.947, 95%CI: 1.630–15.014, P = .005), and the T allele (OR: 3.282, 95%CI: 1.599–5.940, P = .001). TT genotype carriers with elevated cholesterol level ≥ 210 mg/dl, elevated triglyceride level ≥ 155 mg/dl, and decreased HDL-cholesterol level < 36 mg/dl were associated with increased T2DM risk. ConclusionsOur findings suggest the association of ABCA1 (C69T) polymorphism with T2DM in the Egyptian population. Moreover, the ABCA1 TT genotype is associated with increased BMI, hypercholesterolemia, and diminished HDL which confers an increased risk of dyslipidemia and obesity. Further studies are needed to confirm this study results.