Abstract
Vascular endothelial growth factor (VEGF) plays a critical role in ovarian folliculogenesis and normal reproductive function. So far, several studies focusing on association between VEGF gene polymorphisms and polycystic ovary syndrome (PCOS). However, above association between the VEGF gene polymorphisms and PCOS susceptibility is uncertain. Hence, we performed a timely meta-analysis containing all current publications to make clear this relationship. We searched articles from the PubMed, Embase and Chinese language (WanFang and CNKI) databases that were published up until May 10, 2019. Finally, we obtained 9 studies, containing 29 case–control studies and 11 different polymorphisms. The odds ratios (OR) and 95% confidence intervals (CI) were revealed association strengths. There were significantly decreased associations between rs2010963 (-634), +9812, +405 polymorphisms and PCOS risk. Nevertheless, there existed increased associations between rs699947 (-2578), rs833061, rs1570360 (-1154), rs3025020, rs3025039 polymorphisms and PCOS susceptibility. Our current analysis suggested VEGF gene polymorphisms may be associated with PCOS risk, which is possible to be expected to become biomarkers of early detection for women.
Highlights
Polycystic ovarian syndrome (PCOS) is a highly prevalent disorder affecting multiple aspects of a women’s overall health, with long-term effects that transcend well beyond the reproductive age [1,2,3]
We investigated the relationship between genetic variants of the Vascular endothelial growth factor (VEGF) gene single-nucleotide polymorphism (SNP) and PCOS risk by the allelic contrast (1 vs. 2), homozygote comparison (1/1 vs. 2/2), dominant genetic model (1/1+1/2 vs. 2/2), heterozygote comparison (1/2 vs. 2/2) and recessive genetic model (1/1 vs. 1/2+2/2)
9 different articles including 11 SNPs were included in our current meta-analysis (Figure 1)
Summary
Polycystic ovarian syndrome (PCOS) is a highly prevalent disorder affecting multiple aspects of a women’s overall health, with long-term effects that transcend well beyond the reproductive age [1,2,3]. Patients with PCOS demonstrate reproductive abnormalities [5], marked insulin resistance [6], increased risk for Type 2 diabetes mellitus [7], coronary heart disease [8], atherogenic dyslipidemia [9], cerebrovascular morbidity [10], and anxiety and depression [11]. It was first reported in 1935 by Stein et al, the etiology remains unclear. This growth factor induces proliferation and migration of vascular endothelial cells and is essential for both physiological and pathological angiogenesis [14]
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