Association between VDR genetic polymorphisms and risk of gestational diabetes mellitus in the Chinese population.

Abstract

Abnormal metabolism of vitamin D was the primary mechanism in many pregnancy diseases. Our study was the first to examine the hypothesis that VDR gene polymorphisms contribute to the risk of gestational diabetes mellitus (GDM) in the Chinese population at high altitudes. One hundred and eighteen women with GDM and 104 women with normal glucose tolerance (NGT) were included in this study using a case-control design. Four single nucleotide polymorphisms (g.47879112G>A, g.47846052C>T, g.47844974A>G, and g.47845054C>A) of mother and fetus were genotyped. Maternal and fetal frequency of the A allele of g.47879112G>A was significantly increased in women with GDM than in those with NGT (p<.05). A correlation between the AA homozygous genotype of g.47879112G>A and GDM was noted. Compared with non-carriers, A allele carriers showed higher fasting plasma insulin and two-hour post-challenge plasma glucose (2h-PPG), and lower levels of vitamin D. Furthermore, both maternal and fetal 4-marker haplotype ACCG were found to be significantly associated with GDM (p<.05). Association and haplotype analysis indicated that the A allele of g.47879112G>A could be a risk factor for GDM development in the Chinese population at high altitudes. Additionally, the VDR gene polymorphism of the fetus and mother may have a synergistic effect. The VDR polymorphism is associated with an increased risk of GDM and may be useful for predicting the development of the disease.