Effect of gene-lifestyle interaction on gestational diabetes risk.

Polina V Popova,Ekaterina N Kravchuk,Lyudmila B Vasilyeva,Alexandra A Klyushina,Andrey S Gerasimov,Anna A Kostareva,Alexander Predeus,Evgenii A Pustozerov,Alexandra S Tkachuk,Yana A Bolotko,Elena N Grineva

doi:10.18632/oncotarget.22999

Abstract

We hypothesized that the association of certain lifestyle parameters with gestational diabetes mellitus (GDM) risk would depend on susceptibility loci. In total, 278 Russian women with GDM and 179 controls completed questionnaires about lifestyle habits (food consumption, physical activity and smoking). GDM was diagnosed according to the criteria of the International Association of Diabetes and Pregnancy Study Groups. Maternal blood was sampled for genotyping single-nucleotide polymorphisms (SNPs) in MTNR1B (rs10830963 and rs1387153), GCK (rs1799884), KCNJ11 (rs5219), IGF2BP2 (rs4402960), TCF7L2 (rs7903146 and rs12255372), CDKAL1 (rs7754840), IRS1 (rs1801278) and FTO (rs9939609). Binary logistic regression revealed an interaction effect of sausage intake and the number of risk alleles of two SNPs (rs10830963 in MTNR1B and rs1799884 in GCK) on GDM risk (P < 0.001). Among women without risk alleles of these two SNPs, sausage consumption was positively associated with GDM risk (P trend = 0.045). This difference was not revealed in women carrying 1 or more risk alleles. The risk of GDM increased as the number of risk alles increased in participants with low and moderate sausage consumption (P trend <0.001 and 0.006, respectively), while the risk of GDM in women with high sausage consumption remained relatively high, independent of the number of risk alleles. These findings indicate that the association of sausage consumption with GDM risk can be determined based on the number of risk alleles of rs10830963 in MTNR1B and rs1799884 in GCK.

Highlights

Gestational diabetes mellitus (GDM) is one of the most common disorders in pregnancy
These findings indicate that the association of sausage consumption with gestational diabetes mellitus (GDM) risk can be determined based on the number of risk alleles of rs10830963 in melatonin receptor 1B (MTNR1B) and rs1799884 in GCK
The percentage of large-for-gestational-age newborns was higher in the GDM group, there was no difference between the groups in the birth weight or the frequency of delivery by caesarian section

Summary

Introduction

Gestational diabetes mellitus (GDM) is one of the most common disorders in pregnancy. Among the 15 centers that participated in the Hyperglycemia and Adverse Pregnancy Outcome Study, the prevalence of GDM was 17.8% (range 9.3-25.5%), as estimated with the new criteria of the International Association of Diabetes and Pregnancy Study Groups [1]. GDM is associated with significant short- and long-term adverse consequences for the mother and offspring, as it may necessitate caesarean delivery, cause www.impactjournals.com/oncotarget birth trauma [3] and promote the future development of type 2 diabetes (T2D) [4]. In 1980, N Freinkel expanded the hypothesis of Pedersen by describing “fuel-mediated teratogenesis” [6] He pointed out that excessive intake of nutrients causes fetal hyperinsulinemia and predisposes the fetus to hyperinsulinemia throughout life, leading to the development of obesity and diabetes. For the health of mothers and future generations, it is increasingly important to take preventive measures against GDM, detect GDM early, and determine the risk factors in GDM development

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Conclusion