Association between VDR gene FokI polymorphism and renal function in patients with IgA nephropathy.

Man-Qiu Mo,Ling Jiang,Yong-Qing Pan,Zhen-Hua Yang,Ling Pan,Fu-Ji Li,Yun-Hua Liao,Lin Tan

doi:10.7717/peerj.7092

Abstract

BackgroundStudies have shown that the occurrence and development of IgA nephropathy (IgAN) are genetically susceptible, but the relationship between vitamin D receptor (VDR) gene polymorphisms and renal function in IgAN patients is unclear.MethodsWe investigated the relationship between VDR FokI (rs2228570) single nucleotide polymorphism (SNP) and renal function and related clinicopathologic parameters in IgAN patients. Clinical and pathological data of 282 IgAN patients treated at the First Affiliated Hospital of Guangxi Medical University were collected, and FokI genotypes were determined by PCR and direct sequencing. Patients were divided into the renal dysfunction group and normal renal function (control) group by estimated glomerular filtration rate (eGFR) and serum creatinine level.ResultsFrequencies of TT genotype and T allele in the renal dysfunction group were higher than those of the control group. Blood urea nitrogen, serum phosphorus (P), proportions of mesangial cell proliferation, interstitial fibrosis/tubular atrophy and crescents in T allele carriers were higher than those in non-T allele carriers, while eGFR and 25-Hydroxyvitamin D3 were lower in T allele carriers than non-T allele carriers. Multiple linear regression analysis showed that eGFR was affected by FokI genotypes in IgAN patients. Logistics regression analysis showed that middle and elderly age, elevated P, intact parathyroid hormone and TT genotype were independent risk factors for renal dysfunction in IgAN patients; the odds ratio of carrying the TT genotype was as high as 84.77 (P < 0.05 for all).ConclusionsIgA nephropathy patients carrying the VDR FokI TT genotype have an increased risk of renal dysfunction. VDR FokI SNP is closely related to renal function, calcium-phosphate metabolism, and related pathological damage in IgAN patients.

Highlights

As one of the most common primary glomerular diseases, IgA nephropathy (IgAN) results in a high incidence of renal dysfunction, and more than 40% of patients progress toHow to cite this article Mo M-Q, Pan L, Tan L, Jiang L, Pan Y-Q, Li F-J, Yang Z-H, Liao Y-H. 2019
Previous studies have indicated that FokI polymorphism was associated with diabetic nephropathy and lupus nephritis, which increased the susceptibility of chronic renal failure (CRF) (Imam et al, 2017; Razi et al, 2019)
Distribution of FokI genotype and allele frequencies was consistent with Hardy–Weinberg equilibrium (HWE) in enrolled IgAN patients (P > 0.05, Table 1)

Summary

Introduction

As one of the most common primary glomerular diseases, IgA nephropathy (IgAN) results in a high incidence of renal dysfunction, and more than 40% of patients progress toHow to cite this article Mo M-Q, Pan L, Tan L, Jiang L, Pan Y-Q, Li F-J, Yang Z-H, Liao Y-H. 2019. As one of the most common primary glomerular diseases, IgA nephropathy (IgAN) results in a high incidence of renal dysfunction, and more than 40% of patients progress to. Association between VDR gene FokI polymorphism and renal function in patients with IgA nephropathy. We investigated the association between VDR FokI single nucleotide polymorphism (SNP) and renal function and related clinicopathological damage of IgAN. Studies have shown that the occurrence and development of IgA nephropathy (IgAN) are genetically susceptible, but the relationship between vitamin D receptor (VDR) gene polymorphisms and renal function in IgAN patients is unclear. Methods: We investigated the relationship between VDR FokI (rs2228570) single nucleotide polymorphism (SNP) and renal function and related clinicopathologic parameters in IgAN patients. Conclusions: IgA nephropathy patients carrying the VDR FokI TT genotype have an increased risk of renal dysfunction. VDR FokI SNP is closely related to renal function, calcium-phosphate metabolism, and related pathological damage in IgAN patients

Methods

Results

Conclusion