Association between urinary triclosan concentration with bone mass density and osteoporosis in the US adult women, 2005-2010

Abstract

TPS 633: Health effects of pesticides, Johan Friso Foyer, Floor 1, August 27, 2019, 3:00 PM - 4:30 PM Background: Laboratory studies have demonstrated that Triclosan (TCS) could result in significant interstitial collagen accumulation and an increase in trabecular bone. However, little is known about the relationship between TCS exposure and human bone health. Methods: We used 2005-2010 National Health and Nutrition Examination Survey data to examine the association between urinary TCS concentrations with BMD and osteoporosis in the US adult women (age ≥20 years). Weighted analyses were conducted to account for the complex sampling design and to obtain appropriate standard errors (SE), using the NHANES Analytic and Reporting Guidelines. Results: After adjustment for other covariates, significantly negative associations were observed between tertile 3 of TCS concentration and BMD in regions of total femur (β=-0.016, 95% CI=-0.032, -0.000), intertrochanter (β=-0.022, 95% CI=-0.042, -0.002), and lumbar spine (β=-0.014, 95% CI=-0.029, 0.001), respectively, relative to tertile 1. Compared with women at tertile 1, those at tertile 3 had significantly elevated prevalence of osteoporosis in intertrochanter [odd ratio (OR) =2.464, 95% CI = 1.190, 5.105]. Conclusions: In conclusion, this is the first epidemiological study to investigate the association between unariry TCS concentration with BMD and osteoporosis in the US adult women. We found urinary TCS concentration was negatively associated with BMD and was positively associated with prevalence of osteoporosis. The evidence was stronger in postmenopausal women than in premenopausal women. Prospective studies are warranted to validate the findings in the future.