Association between the SstI polymorphism of the apolipoprotein C-III gene, glucose intolerance and cardiovascular risk in renal transplant recipients.

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CARDIOVASCULAR DISEASE (CVD) is the main cause of morbidity and mortality in renal transplant recipients. In addition to lipid abnormalities, insulin resistance may increase the risk of CVD. In the general population, the S2 allele of the SstI polymorphism of the apo C-III gene has been associated with hypertriglyceridemia, high blood pressure, and increased risk of coronary artery disease, all of which are characteristics of the transplant-related insulin-resistant state. However, the influence of apo C-III polymorphism on insulin resistance, dyslipemia, and the development of atherosclerosis in renal transplant recipients is not known.