Abstract
Intercellular adhesion molecule-1 (ICAM-1), an important immune adhesion molecule, is related to the atherosclerosis. We explored the association between the polymorphisms of the ICAM-1 gene and coronary atherosclerotic stenosis to determine whether any risk factors correlate with genetic polymorphisms in Chinese patients with coronary atherosclerosis. Using the SNaPshot assay, we examined six SNPs of rs5491, rs281428, rs281432, rs5496, rs5498 and rs281437 in 604 patients diagnosed with coronary atherosclerotic stenosis by angiography and in 468 controls. We found that AG genotype of rs5498 had higher frequency in the coronary atherosclerotic stenosis patients (41.56% to 34.19%, P = 0.017, OR = 1.368,95%CI 1.057–1.770) and that the haplotype Ars5491Crs281428Grs281432 had higher frequency in patients (13.8% to 12.1%, P = 0.048). When analyzing the clinical risk factors for coronary atherosclerosis, we found that the rs5498 locus was associated with the levels of apolipoprotein A (APOA) (P = 0.0002) and triglycerides (TG) (P = 0.002). Furthermore, the levels of triglycerides (TG) were also associated with rs281432 (P = 0.040). Additionally, the TT genotype of rs281437 was associated with a higher level of apolipoprotein A (APOA) (P = 0.039) and apolipoprotein B (APOB) (P = 0.003). Finally, among those with coronary atherosclerosis, we found no differences in the haplotype analysis of polymorphisms of the ICAM-1 gene from individuals with hypertension or those who smoked. According to our results, the ICAM-1 polymorphisms were associated with risk of coronary atherosclerotic stenosis in Chinese individuals.
Highlights
Coronary heart disease, such as coronary atherosclerosis or ischemic stroke, is a common disease in the elderly population, poses a threat to public health, and can even be life-threatening
The associations between blood pressure and intercellular adhesion molecule 1 (ICAM-1) gene polymorphisms in patients with coronary atherosclerosis are shown in Table 3, We found that those with a GG genotype in rs5498 had a higher frequency of coronary atherosclerosis cases (P = 0.017, odds ratio (OR) = 2.398, 95%confidence interval (CI) 1.151–4.994)
We found no association between the ICAM-1 gene polymorphisms and other risk factors of coronary atherosclerotic stenosis, such as CHO, high-density lipoprotein (HDL), low-density lipoprotein cholesterol (LDL), uric acid (UA) and GLU
Summary
Coronary heart disease, such as coronary atherosclerosis or ischemic stroke, is a common disease in the elderly population, poses a threat to public health, and can even be life-threatening. Interactions between cellular adhesion molecules and their costimulatory receptors, such as ICAM-1 and LFA-1, can transmit signals into leukocytes and cause the migration of leukocytes into the basement membrane of the vasculature. The cellular adhesion molecule ICAM-1, which binds to LFA-1, is important for the firm adhesion of monocytes to the luminal surface of the endothelium. These monocytes can differentiate into foam cells, which participated in the processes of atherosclerotic plaque formation and inflammation in the vasculature [3,4,5]. Single nucleotide polymorphisms (SNPs) of immune functional factors appears to play important roles in cardiovascular disease [8,9,10,11,12]. To investigate the relationship between SNPs of the ICAM-1 gene and the clinical indications of coronary atherosclerosis cases, we analyzed six representative SNPs in the ICAM-1 gene and performed a correlative analysis in patients with coronary atherosclerosis using clinical features collected during examinations
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