Abstract
ObjectiveTo analyze the association between neutrophil‐to‐lymphocyte ratio (NLR) and intravesical prostatic protrusion (IPP) in men with benign prostatic hyperplasia.MethodsTwo hundred and fifty men aged >50 years who presented with lower urinary tract symptoms at our institution between 2014 and 2018 were analyzed. Pearson's method was used for analysis of the correlation between NLR and IPP. Multivariate logistic regression analysis was used to identify predictors of IPP. Further analysis according to total prostate volume (TPV) was performed.ResultsThe NLR correlated positively with IPP (Pearson's r = 0.459, P < 0.001) and was an independent predictor of IPP ≥10 mm (odds ratio, 2.95; 95% confidence interval, 1.59–5.47; P = 0.0006). Among the 142 men with prostates <40 cm3, mean NLR was 2.50 ± 0.71 in those with IPP ≥10 mm and 1.71 ± 0.57 in those with IPP < 10 mm (P < 0.001). The NLR differed significantly between those with a prostate <40 cm3 and IPP ≥10 mm and those with a larger prostate and IPP < 10 mm (2.50 ± 0.71 vs 2.07 ± 0.77, respectively; P = 0.020).ConclusionsNLR can be used as a surrogate marker for presence of IPP. Its clinical value would be especially important in men with a small prostate gland but high IPP. The NLR seemed to be more strongly correlated with IPP than with TPV.
Highlights
Male lower urinary tract symptoms (LUTS) have conventionally been considered as merely the result of age-related prostatic enlargement
total prostate volume (TPV) transitional zone volume (TZV) intravesical prostatic protrusion (IPP) on transrectal ultrasound (TRUS), mm white blood cell (WBC), /μL neutrophil-to-lymphocyte ratio (NLR)
The roles of androgens and growth factors in the onset and progression of benign prostatic hyperplasia (BPH) have been established over the last few decades, and inflammation has been reported to play a role
Summary
Male lower urinary tract symptoms (LUTS) have conventionally been considered as merely the result of age-related prostatic enlargement. Such a simple explanation is not accepted due to the heterogenous characteristics of LUTS and their relationships with systemic diseases.[1]. Numerous studies have demonstrated that benign prostatic hyperplasia (BPH) may be caused by a chronic inflammatory process or immune cell infiltration.[2,3,4,5,6] In response to prostatic inflammation, immune cells generate cytokines that affect other cells to produce growth factors. This is the first study on this topic
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