Association between systolic blood pressure and uric acid in Chinese children and adolescents with idiopathic short stature: a cross-sectional study

Shuang Kou,Ping Li,Hui Pan,Bo Ban,Yanying Li,Qianqian Zhao,Mei Zhang,Baolan Ji

doi:10.1038/s41371-020-0362-0

Abstract

The purpose of this study was to investigate the relationship between systolic blood pressure (SBP) and uric acid (UA) in patients with idiopathic short stature (ISS). The present study was a cross-sectional study. A total of 210 Chinese children and adolescents with ISS were included, and their anthropometrics and biochemical parameters were measured. Growth hormone peak levels were assessed after provocation tests with L-dopa and insulin. The univariate analysis results showed a significant positive association between UA and SBP levels (P < 0.001). Furthermore, a non-linear relationship was detected between UA and SBP. In multivariate piecewise linear regression, the inflection point of UA was 4.13 mg/dl (95% CI 3.28, 6.65; P = 0.03), the levels of SBP increased with the increase in UA when the UA level was >4.13 mg/dl (β 2.63, 95% CI: 0.94, 4.31; P = 0.002). However, we did not observe a significant relationship between UA and SBP when the UA level was <4.13 mg/dl (β −2.72, 95% CI −6.89, 1.45; P = 0.202). Our study found a nonlinear relationship between UA and SBP in Chinese children and adolescents with ISS and showed that SBP levels were associated positively with the rise of UA levels when the UA levels reached the inflection point.

Highlights

These authors contributed : Bo Ban, Ping LiShort stature refers to individuals in a similar living environment and of the same race, same sex and age who are two standard deviations lower than the average height of the normal population
Previous literature has reported that shorter adult heights were associated with higher blood pressure (BP) [7]; Korhonen et al reported that adults with short stature had higher cardiovascular diseases (CVDs) risk and higher BP than the common population [8]
According to previous literature [14, 15], the idiopathic short stature (ISS) criteria is described as follows: individuals which was more than two standard deviation scores (SDS) below the average of the same ethnic, age and sex; individuals with low growth velocity which means the growth velocity of children aged from 4.5 years to without the onset of puberty fail to reach 5 cm per year, or

Summary

Introduction

These authors contributed : Bo Ban, Ping LiShort stature refers to individuals in a similar living environment and of the same race, same sex and age who are two standard deviations lower than the average height of the normal population. For many affected children and adolescents, there are no clear reasons for the identified growth problems. This heterogeneous group of children and adolescents is often described as having ISS. Short stature is considered a risk factor for adult cardiovascular diseases (CVDs), such as coronary heart disease and hypertension [3, 4]. Previous literature has reported that shorter adult heights were associated with higher blood pressure (BP) [7]; Korhonen et al reported that adults with short stature had higher CVD risk and higher BP (especially SBP) than the common population [8].

Objectives

Methods

Results

Discussion

Conclusion