Abstract
Objective The aim of this study was to examine the relationship between insulin-like growth factor-1 (IGF-1) and serum uric acid (UA) in Chinese children and adolescents with idiopathic short stature (ISS). Methods A cross-sectional study of 91 Chinese children and adolescents with ISS was performed. Anthropometric measurements and biochemical parameters were tested. The standard deviation score of IGF-1 (IGF-1 SDS) was calculated. Results A univariate analysis displayed a significant positive correlation between IGF-1 SDS and UA (P = 0.004). In multivariate piecewise linear regression, the levels of IGF-1 SDS increased with the elevation of UA when UA was between 168 μmol/L and 301 μmol/L (β 0.010, 95% CI 0.004–0.017; P = 0.002). The levels of IGF-1 SDS decreased with the elevation of UA when UA was either less than 168 μmol/L (β −0.055, 95% CI −0.081–−0.028; P < 0.001) or more than 301 μmol/L (β −0.005, 95% CI −0.013–0.002; P = 0.174). Conclusions This study demonstrated a nonlinear relationship between IGF-1 and UA levels in Chinese children and adolescents with ISS. This finding suggests that either high or low levels of UA may have an adverse effect on IGF-1, whereas appropriate UA levels have a beneficial effect.
Highlights
The growth hormone-insulin-like growth factor-1 (GH-IGF1) axis is central to the regulation of growth and development
The insulin-like growth factor-1 (IGF-1) standard deviation score (SDS) decreased with the elevation of uric acid (UA) when UA was less than 168 μmol/L (β −0.055, 95% CI −0.081–−0.028; P < 0.001) or more than 301 μmol/L (β −0.005, 95% CI −0.013–0.002; P = 0.174), whereas the IGF-1 SDS increased with the elevation of UA when UA was between 168 μmol/L and 301 μmol/L (β 0.010, 95% CI 0.004–0.017; P = 0.002). In this cross-sectional study, we demonstrated a nonlinear association between IGF-1 SDS and serum UA in Chinese children and adolescents with idiopathic short stature (ISS)
There was a positive relationship between IGF-1 SDS and UA when the concentration of UA was between 168 μmol/L and 301 μmol/L
Summary
The aim of this study was to examine the relationship between insulin-like growth factor-1 (IGF-1) and serum uric acid (UA) in Chinese children and adolescents with idiopathic short stature (ISS). In multivariate piecewise linear regression, the levels of IGF-1 SDS increased with the elevation of UA when UA was between 168 μmol/L and 301 μmol/L (β 0.010, 95% CI 0.004–0.017; P = 0.002). The levels of IGF-1 SDS decreased with the elevation of UA when UA was either less than 168 μmol/L (β −0.055, 95% CI −0.081–−0.028; P < 0.001) or more than 301 μmol/L (β −0.005, 95% CI −0.013–0.002; P = 0.174). This study demonstrated a nonlinear relationship between IGF-1 and UA levels in Chinese children and adolescents with ISS. This finding suggests that either high or low levels of UA may have an adverse effect on IGF-1, whereas appropriate UA levels have a beneficial effect
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