Association Between Systemic Inflamatuary Index and Epicardial Adipose Tissue in Patients with Type 2 Diabetes Mellitus

Abstract

Objective: Epicardial adipose tissue is the visceral fat located between the myocardium and the pericardium. Increases in epicardial adipose tissue are closely associated with the occurrence of cardiovascular diseases. The systemic immune inflammation index is a new parameter developed to determine the inflammatory status of patients. In our study, we aimed to evaluate the relationship between systemic immun inflammation index and epicardial adipose tissue in patients with diabetes mellitus. Method: 119 patients with T2DM and 50 volunteers were included to study. SII was obtained with formulatıon of neutrophil/lymphocyte x platelet. Epicardial fat tissue was obtained by transthoracic echocardiography. The relationship between systemic immune inflammation index and epicardial adipose tissue was evaluated in patients with Diabetes Mellitus Results: In our study, ıt was shown that epicardial adipose tissue was higher in diabetic patients. There was a significant correlation between Body surface area , duration of diabetes mellitus, HbA1c, systemic immune inflammation index, mean platelet volume , neutrophil lymphocyte ratio and epicardial adipose tissue. In linear regression analysis, it was observed that duration of diabetes mellitus (β =0.049 (0.011-0.087); P=0.011) and SII (β=0.013 (0.001-0.018) P=0.008) were independent predictors of EAT. Conclusions: In our study, it was shown that there is a significant relationship between epicardial adipose tissue and systemic immune inflammation index in diabetic patients. In patients with diabetes mellitus, systemic immune inflammation index may provide a useful estimate of epicardial adipose tissue, which has been shown to be associated with cardiovascular events.