Association Between Snvs In Apob, Apoe, Ldlr, Nr5a2, Pcsk9, Ppargc1a And Srebf2 Genes With Desmosterol Concentrations In Patients With Hypercholesterolemia Without Mutations In Candidate Genes

Abstract

Background and Aims: Approximately 20% to 40% of clinically defined familial hypercholesterolemia (FH) cases do not show a causative mutation in candidate genes (mutation-negative FH), and some of them may have a polygenic origin.