Abstract
The aim of the present study was to investigate the relationship of sleep quality and time with basal metabolic rate (BMR) and fuel oxidation in basal conditions and during exercise in sedentary middle-aged adults. We also studied the mediation role of dietary intake and adherence to the traditional Mediterranean Diet in the relationship between sleep parameters and energy metabolism parameters.A secondary analysis of the FIT-AGEING study was undertaken. 70 middle-aged sedentary adults (40–65 years old) participated in the present study. Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI) and wrist accelerometers (ActiSleep, Actigraph, Pensacola, Florida, USA) for 7 consecutive days. BMR was measured with indirect calorimetry and fuel oxidation was estimated through stoichiometric equations. Maximal fat oxidation was determined by a walking graded exercise test and dietary intake with 24 h recalls. Adherence to the traditional Mediterranean diet was assessed through the PREDIMED questionnaire. PSQI global score (poor sleep quality) was associated with lower basal fat oxidation (BFox), both expressed in g/min and as a percentage of BMR, independently of confounders. We did not find any association between other sleep and energy metabolism parameters. No mediating role of the dietary intake or PREDIMED global score was observed in the association of PSQI and BFox. In conclusion, our study showed that a subjective poor sleep quality was associated with lower BFox, which is not mediated by dietary intake in sedentary adults.
Highlights
The aim of the present study was to investigate the relationship of sleep quality and time with basal metabolic rate (BMR) and fuel oxidation in basal conditions and during exercise in sedentary middleaged adults
An inverse association was detected between Pittsburgh Sleep Quality Index (PSQI) global score with basal fat oxidation (BFox), which remained significant after including sex, age and fat mass index (FMI) in the model
PSQI was positively associated with basal carbohydrate oxidation (BCHox) even after controlling for sex, age and FMI
Summary
The aim of the present study was to investigate the relationship of sleep quality and time with basal metabolic rate (BMR) and fuel oxidation in basal conditions and during exercise in sedentary middleaged adults. Nutrient, energy and redox levels signal back to cellular clocks to reinforce circadian rhythms and to adapt physiology (i.e. hormones, body temperature, nervous system) to temporal tissue-specific requirements[11,13] In this sense, previous studies have demonstrated that poor sleep quality and quantity may decrease BMR and BFox[14], and sleep deprivation may not affect MFO www.nature.com/scientificreports in young adults[15]. One of the possible causes of the relationship between sleep parameters with BMR and fuel oxidation could be the dietary modifications In this sense, unhealthy sleep patterns could increase food consumption and energy intake through several previously-explained potential mechanisms[16]. There is a lack of evidence investigating the mediating role of dietary intake in the relationship of sleep outcomes with energy metabolism parameters
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