Abstract
Objective: To explore the association between CETP gene polymorphisms and metabolic syndrome (MS), as well as the relationship between the CETP gene polymorphisms and each component of MS. Methods: A total of 571 individuals which were randomly selected from 5692 Uyghur adults were subdivided into two groups, including 280 patients with MS and 291 control subjects, using the group-matching method after matching for gender. We detected CETP polymorphisms (rs5882, rs1800775, rs3764261, rs12149545, rs711752, and rs708272) by using the Snapshot method. Results: (1) Significant differences were found involving the frequency distribution of genotypes and alleles of rs1800775, rs3764261, rs12149545, rs711752, and rs708272 between the control and MS groups (all p < 0.05). (2) rs1800775, rs3764261, rs12149545, rs711752, and rs708272 polymorphisms were significantly related to the risk of MS (all p < 0.05). (3) The rs1800775 polymorphism was associated with high fasting blood glucose levels and low high density lipoprotein cholesterol (HDL-C); rs3764261 and rs12149545 polymorphisms were associated with all components of MS except high blood pressure; rs711752 and rs708272 polymorphisms were associated with low HDL-C (all p < 0.05). (4) Complete linkage disequilibrium (LD) was identified for two pairs of single nucleotide polymorphisms (SNPs) (rs3764261 and rs12149545 (D’ = 1.000, r2 = 0.931), rs711752 and rs708272 (D’ = 1.000, r2 = 0.996)). (5) The A-G-G-G-C (p = 0.013, odds ratio [OR] = 0.622, 95% confidence interval [95% CI] = 0.427–0.906) and A-T-A-A-T (p < 0.001, OR = 0.519, 95% CI = 0.386–0.697) haplotypes were more frequent in the control group than in the case group. Conclusions: The rs1800775, rs3764261, rs12149545, rs711752, and rs708272 polymorphisms of CETP were associated with MS and its components among the Uyghur ethnic group. Complete LD was found between two pairs of SNPs (rs3764261 and rs12149545, rs711752, and rs708272). The A-G-G-G-C and A-T-A-A-T haplotypes might be protective factors for MS.
Highlights
Metabolic syndrome (MS), which is perceived as a chronic and complex disease, has become a worldwide public health challenge for its concomitant complications over recent years [1]
Complete linkage disequilibrium (LD) was found between two pairs of single nucleotide polymorphisms (SNPs)
The average age, weight, body mass index (BMI), waist circumference, hip circumference, blood pressure, fasting plasma glucose (FPG), TG, total cholesterol (TC), and LDL-C levels were higher in the case group than the control group, while the high density lipoprotein cholesterol (HDL-C) levels were lower in the case group
Summary
We designed a case-control study that included 571 individuals, resident in Jiashi County, Xinjiang. Uyghur Autonomous Region, China, and subdivided into two groups including 280 MS patients and 291 healthy control individuals. All subjects in this study were randomly selected from our previous stratified randomized cluster samples using the group-matching method [25]. Using a self-developed questionnaire, detailed information on demographic and personal lifestyles for each participant was collected during a face-to-face interview by trained investigators. Weight, waist circumference, hip circumference, and blood pressure were measured by trained field workers according to standardized methods [26]. Biochemical tests of blood samples included tests for fasting TG, total cholesterol (TC), HDL-C, LDL-C, and fasting plasma glucose (FPG). All blood detections were analyzed using an automatic biochemical analyzer (AU400, Olympus: Tokyo, Japan). This study was approved by the Institutional Ethics Review Board (IERB) of the First
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