Abstract
This study is aimed at exploring the relationship between serum ferritin and blood lipids and the influence of diabetes and different hs-CRP levels. A total of 8163 subjects were analyzed. Participators were classified according to serum ferritin, diabetes, and two hs-CRP levels. Blood lipids were determined using standardized methods and conditions. Except for HDL-C, there was a significant increase in blood lipids in the progressive ferritin group with normal hs-CRP levels (P < 0.05). But HDL-C was just the opposite (P < 0.0001). In nondiabetic patients, TG, TC, and LDL-C were significantly elevated in the progressive ferritin group (P < 0.05). And, HDL-C was just the opposite (P < 0.05). The generalized linear model and the parsimonious model showed that serum TG was positively correlated with ferritin, and LDL-C was negatively correlated with ferritin (P < 0.05). But the correlation between LDL-C and ferritin was broken (P > 0.05). After a sufficient adjustment, there was a positive correlation between serum TG and ferritin and a negative correlation between LDL-C and ferritin. Nonetheless, a negative correlation between LDL-C and ferritin is influenced by diabetes frailly. And, there was no change of relationship between lipids and ferritin in different hs-CRP levels. We found a real relationship between ferritin and lipids after sufficient adjustment for confounders.
Highlights
In mammals, ferritin should be a way for cells to store iron, rather than transporting iron, whereas the measurement of serum ferritin (SF) levels is widely used for iron status indicators [1]
Correlation analyses revealed a negative correlation between the levels of SF and high-density lipoprotein cholesterol (HDL-C), while positive correlations existed between the levels of SF and triglyceride (TG), total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C) [3]
Our study involved 8163 subjects with an average age of 50.9 years and 46.7% were males. 8.3% of the subjects were with type 2 diabetes (Table 1) and 17.1% with high high-sensitive C-reactive protein (hs-CRP) level
Summary
Ferritin should be a way for cells to store iron, rather than transporting iron, whereas the measurement of serum ferritin (SF) levels is widely used for iron status indicators [1]. Ferritin functions as a clinical biomarker for the evaluation of iron status and plays an important role in energy metabolism disorder. Elevated SF levels are closely related to chronic diseases such as type 2 diabetes (T2D) and cardiovascular disease. Some of the studies showed that elevated serum high-sensitive C-reactive protein (hs-CRP) is related to abnormal lipid metabolism [4]. Vascular experts can consider measuring ferritin levels while assessing lipid and hs-CRP levels. Inflammatory cytokines, hs-CRP, and mortality are related statistics showing that iron-induced oxidative stress may be associated with inflammatory response to PAD [5]
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