Abstract
RAD51D (RAD51L3) is a member of the RAD51 gene family which plays important roles in maintaining genomic stability and preventing DNA damage. This study is aimed to investigate the associations between RAD51D polymorphisms and the hereditary susceptibility of hepatocellular carcinoma (HCC). In this study we conducted a hospital–based case‐control study including 805 cases (HCC patients) and 846 controls (nontumor patients) in Guangxi, China. A total of two Single–nucleotide polymorphisms (SNPs) rs12947947 and rs28363292 of RAD51D were selected and genotyped. Although we did not find two SNPs individually that had any significant main effect on risk of HCC, We found that the combined genotypes with 1‐2 risk genotypes were associated with significantly increased overall risk of HCC (OR = 1.462, 95% CI = 1.050‐2.036). According to the results of further stratification analysis, GT/GG genotype of rs28363292 increased HCC risk in zhuang people (OR = 3.913, 95% CI = 1.873‐8.175) and nonhepatitis B virus (HBV) infection population (OR = 1.774, 95% CI = 1.060‐2.969), the combined 1‐2 risk genotypes increased the risk of HCC in zhuang people (OR = 2.817, 95% CI = 1.532‐5.182) and non‐HBV infected population (OR = 1.567, 95% CI = 1.042‐2.358). Our results suggest that rs12947947 and rs28363292 polymorphisms may jointly contribute to the risk of HCC. Further large studies and functional studies are required to validate our findings.
Highlights
Liver cancer is the fifth most common cancer in the world and the second leading cause of death.[1,2] Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver, and it accounts for between 85% and 90% of these malignancies.[3,4] Each year there are approximately 630 000 new cases of HCC in the world and more than half of the new cases occur in China alone.[5]
We found that the combined genotypes with 1‐2 risk genotypes was associated with significantly increased overall risk of HCC (OR = 1.462, 95% confidence interval (CI) = 1.050‐2.036) (Table 2)
We investigated whether RAD51D gene rs12947947 and rs28363292 polymorphisms are associated with the risk of HCC in the population of South China
Summary
Liver cancer is the fifth most common cancer in the world and the second leading cause of death.[1,2] Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver, and it accounts for between 85% and 90% of these malignancies.[3,4] Each year there are approximately 630 000 new cases of HCC in the world and more than half of the new cases occur in China alone.[5]. Liver cancer is the fifth most common cancer in the world and the second leading cause of death.[1,2]. Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver, and it accounts for between 85% and 90% of these malignancies.[3,4]. Each year there are approximately 630 000 new cases of HCC in the world and more than half of the new cases occur in China alone.[5]. HCC has been regarded as a complicated disease caused by factors including hepatitis. Yan‐Ji Jiang and Jian‐Hong Zhong should be considered joint first author. B virus (HBV) or hepatitis C virus (HCV), tobacco use, and alcohol consumption.[6,7]. The fact that only a small proportion of patients with established risk factors eventually develop HCC suggests that genetic susceptibility may play an important role in HCC development B virus (HBV) or hepatitis C virus (HCV), tobacco use, and alcohol consumption.[6,7] the fact that only a small proportion of patients with established risk factors eventually develop HCC suggests that genetic susceptibility may play an important role in HCC development
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call