Abstract
In order to explore the relationship between peripheral lncRNA expression and coping style in schizophrenia patients, this study screened the peripheral blood mononuclear cells in 5 patients and 5 controls, and 10 differentially expressed lncRNAs were selected and validated in 96 patients and 50 controls by qPCR. Compared to control group, three lncRNAs (NONHSAT089447, NONHSAT021545, NONHSAT041499) were up-regulated in schizophrenia group. Among them, NONHSAT089447, NONHSAT021545 were negatively associated with positive coping style, and other four lncRNAs (ENST00000394742, NONHSAT089447, NONHSAT021545, NONHSAT041499) were positively related to negative coping style. Positive coping style scores in higher-expression of PR4 and PR6 subgroup were significantly lower than those in lower-expression subgroup. While on the other hand, negative coping style scores in higher-expression of NONHSAT089447, NONHSAT021545, NONHSAT041499 subgroup were significantly higher than those in lower-expression subgroup. In conclusion, three lncRNAs (NONHSAT089447, NONHSAT021545, NONHSAT041499) were over-expressed in schizophrenia patients, probably playing a role in the epigenetic process of choosing coping style.
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