Abstract
Background/Aim: Environmental factors may play a role in the development of rheumatic diseases, and some studies have shown that air pollution is associated with the development of autoimmune disease. The study was designed to investigate if particulate matter (PM10) affects development of adult rheumatic diseases including rheumatoid arthritis, ankylosing spondylitis, and systemic lupus erythematosus by using the Kriging data of PM10. Methods: A case-control cohort study was performed using the cohort database during 2010-2013 provided by National Health Insurance Service-National Sample Cohort in Korea. Data of kriging model were collected from the national air pollution monitoring data including PM10. We identified individuals with and without rheumatic diseases during 2013. A total number of 261 cases with rheumatic diseases and 2,871 controls without rheumatic diseases were matched by sex, age group, residential address, income level. Three year average concentrations of PM10 were predicted at each patient’s residence starting from the date of first diagnosis of rheumatic diseases. Results: The arithmetic mean of PM10 was 47.89 μg/m3 in case group and 48.86 μg/m3 in control group. The binary logistic regression analysis, which is adjusted for insurance type showed positive association between PM10 exposure and the occurrence of rheumatic diseases at the age group of 20-44. (OR=1.04, 95% CI: 1.02-1.07) In the sex stratified adjusted model, only male had statistically significant relationship. (OR=1.07, 95% CI: 1.03-1.11) Conclusions: In conclusion, 3 years long-term exposure to PM10 in male showed significantly increased occurrence of rheumatic diseases. Male adult should be aware of PM10 exposure to prevent adverse effect of rheumatic diseases.
Published Version
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