Abstract
This study aimed to investigate the association between p53 Arg72Pro polymorphism and the risk of human papillomavirus (HPV)-related head and neck squamous cell carcinoma (HNSCC) by conducting meta-analysis. The PubMed database was searched for relevant studies until May 30, 2013. Relevant studies were selected and data were extracted by two independent authors. Overall, subgroup, and sensitivity analyses were then conducted using the Comprehensive Meta- Analysis v2.2 software. Wild-genotype ArgArg was considered as reference [odds ratio (OR) = 1.00]. Nine studies involving 1071 HNSCC cases were obtained. Meta-analysis results indicated no association between p53 Arg72Pro polymorphism and the risk of HPV-related HNSCC: for Pro/Pro vs. Arg/Arg, OR = 1.17, 95% confidence interval (CI) = 0.70-1.98; for Arg/Pro vs. Arg/ Arg, OR = 1.25, 95% CI = 0.97-1.72; and for (Pro/Pro + Arg/Pro) vs. Arg/Arg, OR = 1.28, 95% CI = 0.95-1.70. These meta-analysis results were supported by subgroup and sensitivity analysis results. In conclusions, p53 Arg72Pro polymorphism is a potential marker of HP infection-related HNSCC rather than a susceptibility gene polymorphism.
Highlights
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide (Moore et al, 2000; Kamangar et al, 2006; Warnakulasuriya, 2009)
P53 gene is located at chromosome 17p13 and considered as one of the most frequently mutated genes in human carcinogenesis (Tsui et al, 2009). rs1042522 polymorphism is located in exon 4 of p53 gene, in which an arginine (Arg)gproline (Pro) amino acid substitution is present at amino acid position 72; such polymorphism is commonly named Pro72Arg or codon polymorphism (Ara et al, 1990)
Studies have not yet elucidated whether or not p53 Arg72Pro polymorphism merely functions as a marker of human papillomavirus (HPV)-related HNSCC cases
Summary
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide (Moore et al, 2000; Kamangar et al, 2006; Warnakulasuriya, 2009). The classical risk factors of HNSCC include tobacco, alcohol, and human papillomavirus (HPV) (Farris et al, 2013; Galbiatti et al, 2013). Epidemiological studies have indicated that p53 Arg72Pro polymorphism increases the risk of many cancers, such as cutaneous melanoma (Oliveira et al, 2013), bladder cancer (Xu et al, 2012), and nasopharyngeal carcinoma (Zhuo et al, 2009). Studies have not yet elucidated whether or not p53 Arg72Pro polymorphism merely functions as a marker of HPV-related HNSCC cases. For these reasons, we conducted meta-analysis to estimate the relationship between p53 Arg72Pro polymorphism and the risk of HPV-related HNSCC
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