The Genetic Polymorphisms in the MIR17HG Gene Are Associated with the Risk of Head and Neck Squamous Cell Carcinoma in the Chinese Han Population.

Chongwen Xu,Zhen Shen,Yanxia Bai,Peng Han,Wanli Ren,Baiya Li,Yuan Shao,Hao Dai,Sercan Erg N

doi:10.1155/2020/2329196

Abstract

Purpose Head and neck squamous cell carcinoma (HNSCC) is the most common malignant tumors in the world. Genetic variants have an important role in HNSCC progression. Our study is aimed at exploring the relationship between MIR17HG polymorphisms and HNSCC risk in the Chinese Han population. Methods We recruited 537 HNSCC cases and 533 healthy subjects to detect the correlation of six polymorphisms in MIR17HG with HNSCC susceptibility. The associations were evaluated by computing odds ratios (ORs) and 95% confidence intervals (CIs) using logistic regression analysis. Results Our study revealed that rs7336610 (OR 1.77, 95%CI = 1.09‐2.86, and p = 0.021) and rs1428 (OR 1.73, 95%CI = 1.07‐2.81, and p = 0.025) are strongly associated with increased susceptibility to HNSCC in men. Besides, rs17735387 played a crucial protective role in stage III/IV HNSCC patients (OR 0.34, 95%CI = 0.12‐0.95, and p = 0.040) compared with stage I/II. Conclusion Our study firstly indicated that MIR17HG polymorphisms are significantly associated with HNSCC susceptibility, which suggests that MIR17HG has a potential role in the occurrence of HNSCC.

Highlights

Head and neck squamous cell carcinoma (HNSCC) is the most common malignant tumors, which includes tumors from the oral cavity, hypopharynx, pharynx, and larynx
Numerous studies suggested that polymorphisms of some Long noncoding RNA (lncRNA) included in PTENP1, and HOTAIR are significantly associated with HNSCC susceptibility [8, 9]
Our result indicated that rs7336610 (TC vs. TT, odds ratios (ORs) 1.77, 95% confidence intervals (CIs) = 1:09‐2:86, and p = 0:021; TC-CC vs. TT, OR 1.64, 95%CI = 1:04‐2:57, and p = 0:030) and rs1428 (AC vs. AA, OR 1.73, 95%CI = 1:07‐ 2:81, and p = 0:025; AC-CC vs. AA, OR 1.63, 95%CI = 1:04‐ 2:56, and p = 0:035) polymorphisms are strongly associated with an increased risk of HNSCC in men (Table 4)

Summary

Introduction

Head and neck squamous cell carcinoma (HNSCC) is the most common malignant tumors, which includes tumors from the oral cavity, hypopharynx, pharynx, and larynx. Increased studies revealed that genetic factors have a crucial effect on the occurrence of HNSCC. Some studies indicated that lncRNAs participate in the progression and development of HNSCC by regulating the behavior of HNSCC cells [5,6,7]. Numerous studies suggested that polymorphisms of some lncRNAs included in PTENP1, and HOTAIR are significantly associated with HNSCC susceptibility [8, 9]. Taken together, it suggests that genetic variants of lncRNAs may have a crucial role in HNSCC progression

Methods

Results

Conclusion