Association between Oxidative Stress Assessed by Urinary 8-Hydroxydeoxyguanosine and the Cardiac Function in Hypertensive Patients without Overt Heart Disease

Abstract

Although increased oxidative stress is known to be associated with worsened cardiac function in chronic heart failure, consensus is still lacking regarding the association between oxidative stress and cardiac function in hypertensive patients without overt heart disease. This study aimed to evaluate the association between oxidative stress assessed by urinary 8-hydroxydeoxyguanosine (8-OHdG) and cardiac function in hypertensive patients without overt heart disease. We enrolled a total of 80 hypertensive patients (70 ± 11 y) who had been taking antihypertensive medications for at least 1 year. Urinary 8-OHdG levels were measured by an immunochromatographic assay (ICR-001, Selista Inc., Tokyo, Japan). Echocardiography was performed to assess the left ventricular (LV) diastolic function by measuring early diastolic mitral annular velocity (e′) and the ratio of early transmitral flow velocity (E) to e′ (E/e′). Urinary 8-OHdG was correlated with E/e′ (r = 0.346, P = .002), e′ (r = −0.310, P = .005), and HbA1c (r = 0.276, P = .013). Multiple linear regression analysis revealed that only e′ (β = −0.343, P = .004) was an independent determinant of urinary 8-OHdG. In conclusion, decreased e′ is independently associated with elevated urinary 8-OHdG, a marker of oxidative stress, in hypertensive patients. Therefore, an elevated urinary 8-OHdG level may be useful in detecting subclinical LV diastolic dysfunction in hypertensive patients without overt heart disease.