Association Between Maximum Standardize Uptake Value and Prognostic Factors at Endometrioid Type Endometrial Carcinoma

Varol Gulseren,Mehmet Gokcu,Mustafa Kocaer,Ozgu Gungorduk,Kemal Gungorduk,Isa Aykut Ozdemir,Muzaffer Sanci,Ilker Cakir

doi:10.21613/gorm.2018.817

Abstract

Objective: Investigate the relationship between the maximum standardize uptake value (SUVmax) values and the prognostic factors in endometrioid-type endometrial cancer (EEC) patients undergoing preoperative positron emission tomography / computed tomography (PET/CT).Study Design: We reviewed retrospectively the records of patients with EEC diagnosis who underwent hysterectomy in Gynecologic Oncology Clinic of Tepecik Training and Research Hospital between January 2010 and January 2017 in this retrospective study. Receiver operating characteristic (ROC) curve analysis was performed to determine the cut-off values of SUVmax for predicting clinical parameters. The area under the ROC curve (AUC) is presented as a measure of discrimination.Results: It was calculated that the SUVmax values in the uterine tumor were higher and statistically significant in the presence of advanced stage (III-IV), histologic grade III, deep myometrial invasion (≥1 / 2) and large tumor size (≥4 cm) from prognostic factors. The SUVmax values of the groups with and without cervical invasion did not different from each other. In order to use the SUVmax value as a diagnostic test in the ROC analysis, the AUC values were as follows; the grade of advanced stage tumor was 0,685, the grade 3 tumor was 0,797, the depth of myometrial invasion was 0,781, and the size of the large tumor was 0,905.Conclusion: SUVmax value in primary uterine tumor was found to be higher in prognostic factors in patients with advanced stage, high grade, deep myometrial invasion and large tumor.

Highlights

Endometrial cancer is the most common gynecologic malignancy in developed countries (1-3)
It was calculated that the SUVmax values in the uterine tumor were higher and statistically significant in the presence of advanced stage (III-IV), histologic grade III, deep myometrial invasion (≥1 / 2) and large tumor size (≥4 cm) from prognostic factors
SUVmax value in primary uterine tumor was found to be higher in prognostic factors in patients with advanced stage, high grade, deep myometrial invasion and large tumor

Summary

Introduction

Endometrial cancer is the most common gynecologic malignancy in developed countries (1-3). The prognosis of patients with endometrioid-type endometrial cancer (EEC) is excellent because they are usually at an early stage when diagnosed (2). Prognosis in EEC is related to stage, age of the patient, histological type and grade of the tumor, cervical invasion, depth of myometrial invasion, lymph node involvement and distant organ metastasis (1,2). There is a significant prognostic difference between the histological types of endometrium carcinoma. EEC type-1 is known as estrogen sensitive endometrial carcinomas and is a good prognostic indicator (3). Stage is considered the most important prognostic factor (3). The most commonly used methods to estimate the preoperative stage of surgery are the histological type and grading of the tumor obtained after the histopathological examination of the curettage material and magnetic resonance imaging, which provides better information about solid organs among imaging methods

Methods

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Discussion

Conclusion