Association between liver function and metabolic syndrome in Chinese men and women

Sen Wang,Qing Zhang,Na Liu,Zhaowei Meng,Kun Song,Linlin Song,Jie Zhang,Li Liu,Qiang Jia,Qiyu Jia,Li Zhu,Pingping Zhou,Xue Li,Tianpeng Hu

doi:10.1038/srep44844

Sen Wang, Qing Zhang + Show 12 more

Open Access

PDF Available

https://doi.org/10.1038/srep44844

Copy DOI

Export

Save

Cite

Abstract
Highlights/Summary
Full-Text PDF
Similar Papers

Abstract

Listen

Metabolic syndrome (MS) could be associated with liver function. Our study aimed to investigate the association between liver function and MS in a large cohort of Chinese men and women. We enrolled 32,768 ostensibly healthy participants. The associations between liver function and MS of both genders were analyzed separately after dividing total bilirubin (TBIL), gamma glutamyltransferase (GGT), alanine aminotransferase (ALT) into quartiles. Young males had significantly higher MS prevalence than females, yet after menopause, females had higher MS prevalence. We used TBIL, GGT and ALT quartiles as categorical variables in binary logistic regression models. Significantly decreased MS risks were demonstrated in TBIL quartiles 2 to 4 for males, and quartiles 3 to 4 for females. As to GGT and ALT, significantly increased MS risks were shown in high quartiles for both genders. Aging also resulted in significantly higher MS risks in both genders except for young females. This study displayed close associations between liver function and MS, which were influenced by gender and age. A high TBIL level had protective effect against MS, while high GGT and ALT levels were risk factors for MS. It is meaningful that liver function is used as clinical risk predictors for MS.

Highlights

The objective of this cross-sectional study was to investigate correlations between liver function and Metabolic syndrome (MS) with emphasized focuses on differences generated from age and gender in a representative sample of Tianjin municipality population
high-density lipoprotein cholesterol (HDL) and total cholesterol (TC) in males were lower than those values in females
Females, age demonstrated a negative correlation with HDL only, yet positive correlations with Body mass index (BMI), waist circumference (WC), systolic blood pressure (SBP), diastolic blood pressure (DBP), TBIL, GGT, ALT, low-density lipoprotein (LDL), TC, TG, blood urea nitrogen (BUN), uric acid (UA), Cr and fasting glucose (FG)

Summary

Introduction

The objective of this cross-sectional study was to investigate correlations between liver function and MS with emphasized focuses on differences generated from age and gender in a representative sample of Tianjin municipality population. The indices representing hepatic function (TBIL, GGT and ALT) were significantly higher in males than those in females. Age demonstrated positive correlations with WC, SBP, DBP, LDL, HDL, TC, BUN, Cr and FG, yet negative correlations with GGT, ALT, TG and UA in males.

Results

Conclusion