Abstract
Association between Lipid Levels and Short-Term Heart Rate Variability (HRV) In Type 2 Diabetes
Highlights
Heart Rate Variability (HRV) assesses the integrity of the autonomic nervous system as it is influenced by the changes in the sympathetic as well as the vagal activity (Electrophysiology, 1996)
In type 2 diabetics, when the normal total cholesterol group is compared with the high total cholesterol group (Table 1), Standard deviation of all NN intervals (SDNN) (p= 0.036) and High Frequency (HF) power (p= 0.040) showed a statistically significant reduction
This is statistically significant for total cholesterol (p=0.002) after adjustment for age, Body Mass Index (BMI), and other lipid parameters
Summary
Heart Rate Variability (HRV) assesses the integrity of the autonomic nervous system as it is influenced by the changes in the sympathetic as well as the vagal activity (Electrophysiology, 1996). The time-domain measures considered in this study are Standard Deviation of all NN intervals (SDNN), Square Root of the Mean of the Sum of the Squares of the Differences between adjacent NN intervals (RMSSD), and the number of pairs of adjacent NN intervals differing more than 50 milliseconds in the entire recording divided by the total number of NN intervals (pNN50) Of these three, SDNN is a measure of total variability while RMSSD and pNN50 estimate highfrequency variations in heart rate (Electrophysiology, 1996). Methods: As per the set criteria, 70 newly diagnosed type 2 diabetics were recruited and grouped based on their cholesterol levels Both the time domain and the frequency domain measures of short-term HRV were acquired and subjected to statistical analysis. Based on this we conclude abnormal lipid levels depress HRV
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