Abstract
BackgroundThe associations between the interleukin-4 receptor α chain (IL4RA) I50V and Q551R polymorphisms and asthma risk remained controversial.MethodsWe searched the Pubmed, Embase, Chinese National Knowledge Infrastructure (CNKI) and Wanfang databases for studies published before February 2013. The strengths of the associations were calculated using odds ratios (ORs) with 95% confidence intervals (CIs).ResultsA total of 50 studies were included in this meta-analysis. There was a significant association between the IL4RA I50V polymorphism and asthma risk in a dominant genetic model (OR = 1.13, 95% CI 1.04–1.23, P = 0.005). The IL4RA Q551R polymorphism was associated with a significantly elevated asthma risk in a recessive genetic model (OR = 1.46, 95% CI 1.22–1.75, P<0.0001). Subgroup analyses found that the IL4RA I50V polymorphism was significantly associated with asthma risk in Asians (OR = 1.72, 95% CI 1.31–2.25, P<0.0001), pediatric asthma risk (OR = 1.50, 95% CI 1.13–1.99, P = 0.005), and atopic asthma risk (OR = 1.88, 95% CI 1.27–2.79, P = 0.002).ConclusionsThe results of this meta-analysis suggested that the IL4RA I50V and Q551R polymorphisms may be risk factors for developing asthma.
Highlights
Asthma is a complex, persistent, inflammatory disease characterized by airway hyper-responsiveness and inflammation
Kotsimbos et al [4] showed that expression levels of IL-4Ra messenger RNA and protein were significantly increased in the epithelium and subepithelium of biopsy specimens from subjects with atopic asthma, compared with atopic control subjects
Knowledge Infrastructure (CNKI), and Wanfang databases was conducted for studies published before February 2013 using combinations of the following terms: and and
Summary
Persistent, inflammatory disease characterized by airway hyper-responsiveness and inflammation. T helper-2 (Th2) cytokines, such as interleukin-4 (IL-4) and IL13, play central roles in allergic inflammation and asthma. They exert their biological activities by binding to their respective cell surface receptors, both of which share the a chain of the IL-4 receptor (IL-4Ra) [3]. IL-4Ratargeted antibodies could reduce lung inflammation, airway hyper--responsiveness and goblet-cell hyperplasia in mouse models of asthma [6]. These results indicated that IL-4Ra may play an important role in the pathogenesis of asthma and suggested that IL4RA may be a strong candidate gene for asthma susceptibility. The associations between the interleukin-4 receptor a chain (IL4RA) I50V and Q551R polymorphisms and asthma risk remained controversial
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