Abstract
BackgroundEvidence is increasingly accumulated about multiple roles for the β2-adrenoceptor gene in asthma. The results were inconsistent partly due to small sample sizes. To assess the association between β2-adrenoceptor gene polymorphisms and asthma risk, a meta-analysis was performed.MethodsWe comprehensively searched the PubMed, EMBASE, BIOSIS Previews databases and extracted data from all eligible articles to estimate the association between β2-adrenoceptor gene polymorphisms and asthma risk. The pooled odds ratio (OR) with 95% confidence intervals (CIs) were calculated.ResultsThirty-seven studies involving 6648 asthma patients and 15943 controls were included in the meta-analysis. Overall, significant associations were found in allelic genetic model (OR = 1.06, 95% CI = 1.01∼1.12), recessive genetic model (OR = 1.11, 95% CI = 1.02∼1.21) for Arg/Gly16. Stratified by ethnicity and age, significant associations were also found in Asian population in allelic genetic model, recessive genetic model and addictive model. For Gln/Glu27, no significant association was found when we combined all eligible studies. Age stratification showed significant associations in adults in allelic genetic model and recessive genetic model, but no significant association was found among Asians and Caucasians in ethnicity stratification.ConclusionsThis meta-analysis implied that the β2-adrenoceptor Arg/Gly16 polymorphism was likely to contribute to asthma risk in Asian population. Gln/Glu27 polymorphism might be a contributor to asthma susceptibility for adults.
Highlights
Asthma is a common chronic disorder of the airways, which is characterized by airway hyperresponsiveness, obstruction, and airway wall remodeling [1]
Considerable efforts have been made to evaluate the association between genetic variants and asthma risk, and numerous genes have been identified as asthma susceptible genes [5,6,7]
The remaining 155 articles were assessed for inclusion and 120 articles were excluded (98 records excluded for irrelevance, 15 records no detailed genotypes, 4 depart from Hardy-Weinberg equilibrium (HWE), 3 duplicate publications)
Summary
Asthma is a common chronic disorder of the airways, which is characterized by airway hyperresponsiveness, obstruction, and airway wall remodeling [1]. The b2AR gene is located on chromosome 5q31-q32, a region that is genetically linked to asthma and related phenotypes [9]. Many studies have investigated these polymorphisms to assess their potential contributions to the risk of asthma. It was observed in some studies that b2AR gene may play a significant role in the pathogenesis of asthma [11,12,13,14,15,16]. Other studies showed no association between asthma and b2AR gene polymorphisms [17,18,19,20,21,22]. Additional many studies with large sample sizes about b2AR polymorphisms on asthma risk have been reported. To assess the association between b2-adrenoceptor gene polymorphisms and asthma risk, a meta-analysis was performed
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