Association between interleukin-10-819T/C polymorphism and risk of ischemic stroke: A meta-analysis.

Abstract

Background:The interleukin-10 (IL-10)-819T/C polymorphism has been indicated to be correlated with ischemic stroke susceptibility, but this relationship remains controversial. A meta-analysis was conducted to investigate the potential association between IL-10-819T/C polymorphism and ischemic stroke risk.Methods:Databases including Pubmed, Embase, and CNKI were searched. Data were extracted and odds ratios (OR) with 95% confidence intervals (CI) were calculated.Results:Eight case-control studies with 1832 cases and 1520 controls were included in this meta-analysis. IL-10-819T/C polymorphism may decrease the risk of ischemic stroke (C vs T: OR = 1.01, 95% CI: 0.91–1.12; CC vs TT: OR = 0.91, 95% CI: 0.73–1.14; CT vs TT: OR = 1.10, 95% CI: 0.95–1.28; CC + CT vs TT: OR = 1.06, 95% CI: 0.92–1.22; CC vs CT + TT: OR = 0.91, 95% CI: 0.75–1.11). In the stratified analysis by sample size, and case-control matched status, significant associations were still not observed in all genetic models. In the subgroup meta-analysis based on source of controls, IL-10-819T/C polymorphism had decreased ischemic stroke risk for recessive model in population-based controls’ subgroup (CC vs CT + TT: OR = 0.69, 95% CI: 0.50–0.95), but not in the hospital-based controls’ subgroup. In the stratified analysis based on ethnicity, IL-10-819T/C polymorphism had decreased ischemic stroke risk for recessive model in Asian populations (CC vs CT + TT: OR = 0.78, 95% CI: 0.62–0.99), but not in Caucasian populations.Conclusions:In conclusion, the results suggest that the IL-10-819T/C polymorphism is not associated with ischemic stroke risk. Larger scale studies are needed for confirmation.