Abstract
Background and objective: Interleukins (ILs), as important biochemical mediators, control the host response to inflammation and are associated with bone resorption. In the present meta-analysis, we investigated the association between IL−1 polymorphisms and susceptibility to dental peri-implant disease (PID). Materials and methods: We searched Web of Science, Cochrane Library, Scopus, and PubMed/Medline databases for studies published until 9 September2021, without any restrictions. We calculated the crude OR and 95% confidence intervals (CI) to estimate the associations between IL−1 polymorphisms and PID risk in the five genetic models. We further performed the subgroup analysis, sensitivity analysis, meta-regression, trial sequential analysis, and calculated the publication bias. Results: Out of 212 retrieved records, sixteen articles were used in the meta-analysis. There was no association between IL−1A (–889), IL−1B (−511), IL−1B (+3953), and IL−1RN (VNTR) polymorphisms and the risk of dental PIDs, but there was an increased risk of IL−1B (+3954) in the patients with PIDs. In addition, an association of the composite genotype of IL−1A (−889)/IL−1B (+3953) was observed with the risk of PIDs, but not for the composite genotype of IL−1A (−889)/IL−1B (+3954). The publication year, the ethnicity, sample size, and the outcome were significantly influenced pooled estimates of some genetic models. Trial sequential analysis showed the lack of sufficient sample sizes in the studies. Conclusions: Among IL−1 polymorphisms evaluated in the meta-analysis, the composite genotype of IL−1A (−889)/IL−1B (+3953) and IL−1B (+3954) were the only polymorphisms associated with the risk of PID. The T allele and CT genotype of IL−1B (+3954) polymorphism were also associated with an elevated risk of PID.
Highlights
Dental implants are currently considered an effective treatment for functional and cosmetic rehabilitation of patients with partial or complete edentulousness [1,2]
23 articles were excluded with reasons (5 were systematic reviews, 3 were meta-analyses, 5 were reviews, 2 had no control groups, 1 was book chapter, included less than 10 cases, 1 had a control group demonstrating HWE deviation, and had insufficient data to estimate the odds ratios)
The results showed that the ethnicity and the outcome were two significant factors that could affect the pooled estimates for the association between alleles, genotypes of IL−1A (−889) polymorphism and the risk of dental peri-implant disease (PID) in heterozygous and recessive models
Summary
Dental implants are currently considered an effective treatment for functional and cosmetic rehabilitation of patients with partial or complete edentulousness [1,2]. The clinical success of dental implants is based on the principle of osseointegration, which involves bone growth in metal implants. Peri-implantitis can lead to bone loss and implant failure [4,5]. Peri-implantitis, marginal bone loss, and implant failure are three outcomes associated with peri-implant diseases (PIDs) [6,7]. We investigated the association between IL−1 polymorphisms and susceptibility to dental peri-implant disease (PID). We calculated the crude OR and 95% confidence intervals (CI) to estimate the associations between IL−1 polymorphisms and PID risk in the five genetic models. There was no association between IL−1A (–889), IL−1B (−511), IL−1B (+3953), and IL−1RN (VNTR) polymorphisms and the risk of dental PIDs, but there was an increased risk of
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