Abstract
Background: PM2.5 exposure is known to have adverse effect on respiratory function in children. However, most of the previous studies were based on the ecological evaluation of outdoor exposure. The aim of the present study is to examine the association between individually monitored indoor PM2.5 concentration and peak expiratory flow rate (PEFR).Methods: We recruited 30 9-year-old children to conduct a panel study. Each child’s PM2.5 exposure was measured using indoor air quality station equipped with light-scattering particle sensor. The indoor air quality stations were installed at the children’s classrooms and each child’s bedroom at their homes. We calculated daily mean concentration for each child according to the time spent at each place. PEFR was measured using peak expiratory flow meter at their class rooms (during week days) and homes (during weekend) between 8 and 9 AM for 6 consecutive days. We measured the children’s heights and weights to calculate the body mass index (BMI), and a questionnaire was administered to obtain information on covariates. We constructed mixed linear model to examine the association adjusting for age (months), sex, BMI, environmental tobacco smoke exposure and monthly average household income.Result: A total of 115 observations were included in the present analysis. The daily average PM2.5 concentrations were between 38.6±11.6 and 67.3±15.8 μg/m3. The daily average PEFRs were between 266.1±48.57 and 276.2±48.86 L/min. The regression coefficient of PEFR (L/min) for the increment of 10 μg/m3 of daily mean concentration of PM2.5 was -2.27 (SE: 0.14, P-value: 0.098).Conclusion: We observed marginally significant adverse association between individually monitored PM2.5 concentration and PEFR in 9-year-old children.
Published Version
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