Association between HLA-A gene polymorphism and early-onset preeclampsia in Chinese pregnant women early-onset

Yuanyuan Zheng,Weiyuan Zhang,Shaowen Wu,Shenglong Zhao,Xiaowei Liu,Cui Ma

doi:10.1186/s12884-020-03340-w

Yuanyuan Zheng, Weiyuan Zhang + Show 4 more

Open Access

https://doi.org/10.1186/s12884-020-03340-w

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Abstract

BackgroundPreeclampsia is an idiopathic disease during pregnancy. This study explores the correlation between HLA-A polymorphism and the onset of preeclampsia.MethodsThe Illumina HiSeq2500 sequencing platform was used to genotyping HLA-A allele in venous blood DNA of 50 preeclampsia pregnant women and 48 normal pregnant women and umbilical cord blood DNA of their children of Han nationality in China. The frequencies and distributions of alleles and genotypes among the mothers and their children were compared between the two groups. The differences of frequencies and distributions of genotypes were compared between the two groups according to the mothers’ genotype compatibility.ResultsTwenty HLA-A alleles were detected in preeclampsia pregnant women and normal pregnant women; 21 HLA-A alleles were found in preeclampsia group fetuses and 22 HLA-A alleles in control group fetuses. There was no statistical difference in the HLA-A genes’ frequency between the two groups of pregnant women and their fetuses. When the sharing antigen was 1, the number of maternal-fetal pairs in the preeclampsia group was more than that in the control group; the difference was statistically significant (P < 0.05). The frequency of neither mother nor fetus carrying the HLA-A * 24: 02 gene in the preeclampsia group was significantly lower than that in the control group (P < 0.05). HLA-A gene homozygosity in fetuses of early-onset preeclampsia group was substantially higher than that of the control group (P = 0.0148); there is no significant difference in pregnant women’s genes homozygosity between early-onset preeclampsia group and the control group.ConclusionsHLA-A * 24: 02 may be a susceptibility gene for early preeclampsia.

Highlights

Preeclampsia is an idiopathic disease during pregnancy
The pathogenesis of early-onset preeclampsia has not been cleared yet, the characteristic pathology of early-onset preeclampsia turns into uterine spiral artery remodeling disorder, shallow placenta implantation, and the arterial pathology of the placental bed in patients became similar to acute transplant rejection, which are summarized in placental disease [4]
This study explores the relationship between Human leukocyte antigen (HLA)-A polymorphism and the early-onset preeclampsia, and lays the foundation for further elucidating the pathogenesis of earlyonset preeclampsia

Summary

Introduction

Preeclampsia is an idiopathic disease during pregnancy. This study explores the correlation between HLA-A polymorphism and the onset of preeclampsia. The clinical manifestations of preeclampsia are hypertension and/or proteinuria after 20 weeks of pregnancy, accompanied by systemic organ function damage and placenta function damage, which seriously endangers mothers and children [1]. It is the leading cause of maternal death and an essential reason for increasing perinatal incidence and mortality. The pathogenesis of early-onset preeclampsia has not been cleared yet, the characteristic pathology of early-onset preeclampsia turns into uterine spiral artery remodeling disorder, shallow placenta implantation, and the arterial pathology of the placental bed in patients became similar to acute transplant rejection, which are summarized in placental disease [4]

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Conclusion