Abstract
Association between High Sensitive-C Reactive Protein and Lipid Cardiovascular Risk Factors in Apparently Healthy Nigerian Young Adults
Highlights
Atherosclerosis remains the major cause of death in developing and developed countries, regardless of the various differences in ethnicities, habits, cultures and availability of affordable therapies [1].It’s a known fact that 50% of all myocardial infarctions occur among individuals without overt hyperlipidaemia, inspite of the strong association of lipid concentrations with coronary heart disease risk (CHD) [2]
Chronic inflammatory process which starts from childhood tracking to adulthood has been reported to play a major role in the development and progression of atherogenesis leading to coronary heart disease. high sensitivity C-reactive protein (hs-C-reactive protein (CRP)), an inflammatory marker has been shown to best predict development of cardiovascular disease (CVD) even in the absence of traditional risk factors
This study has demonstrated that increase in central or visceral adiposity, plasma total cholesterol, triglycerides, ApoB; and decreases in plasma HDL-cholesterol and ApoA1, can invoke vascular inflammation which can be detected early by rising concentration of hs-CRP even in young individuals yet to develop CVD
Summary
Atherosclerosis remains the major cause of death in developing and developed countries, regardless of the various differences in ethnicities, habits, cultures and availability of affordable therapies [1].It’s a known fact that 50% of all myocardial infarctions occur among individuals without overt hyperlipidaemia, inspite of the strong association of lipid concentrations with coronary heart disease risk (CHD) [2]. It has been shown that about 20% of all coronary events occurred in the absence of any of the traditional risk factors, such as hypertension, diabetes mellitus, hyperlipidaemia and smoking [3] These findings raise the query if these conventional risk factors are sufficient to recognize individuals at increased risk of CHD. Various non-lipid atherogenic markers have been suggested in an effort to better determine individuals at risk of CHD, these include markers of inflammation (high sensitivity C-reactive protein, interleukins, adhesion molecules, heat shock proteins); markers of fibrinolytic and haemostatic function (D-dimers, fibrinogen, thrombinantithrombin III complex); homocysteine to mention but few. Conclusions: This study has demonstrated that increase in central or visceral adiposity, plasma total cholesterol, triglycerides, ApoB; and decreases in plasma HDL-cholesterol and ApoA1, can invoke vascular inflammation which can be detected early by rising concentration of hs-CRP even in young individuals yet to develop CVD
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