Abstract
BackgroundAccumulating evidence suggests that high-density lipoprotein (HDL) cholesterol is associated with pulmonary function and pulmonary disorders. The aim of this study was to evaluate the association between HDL cholesterol and pulmonary function in healthy adolescents.MethodsThis cross-sectional study was based on data collected for the JS High School study. The analysis included 644 adolescents (318 male and 326 female) aged 15–16 years old and free from asthma or chronic obstructive pulmonary disease. Fasting blood samples were collected for hematologic and biochemical assessment. Forced vital capacity volume (FVC) and forced expiratory volume in the 1 s (FEV1) were measured using dry-rolling-seal spirometry. The associations between HDL cholesterol and pulmonary function were analyzed using multiple linear regression models.ResultsAmong male adolescents, an increase of 1.0 mg/dL in HDL cholesterol was associated with 10 mL decrease in FVC (p = 0.013) and FEV1 (p = 0.013) after adjusting for age, height, weight, alcohol drinking, smoking, physical activity, systolic blood pressure, total cholesterol, triglyceride, and monthly household income. Percent predicted values of FVC (p = 0.036) and FEV1 (p = 0.017) were also inversely associated with HDL cholesterol. However, among female adolescents, HDL cholesterol level was not significantly associated with absolute or percent predictive value of FVC and FEV1.ConclusionsHigher HDL cholesterol level may be associated with decreased pulmonary function among healthy male adolescents. The sex differences observed in the association between HDL cholesterol and pulmonary function need further investigation.
Highlights
Accumulating evidence suggests that high-density lipoprotein (HDL) cholesterol is associated with pulmonary function and pulmonary disorders
HDL is found associated with apolipoprotein M more than other lipoproteins for the reason that apolipoprotein M is important for the formation of pre-beta HDL and for reverse cholesterol transport [1, 2]
Pulmonary function indices such as Forced vital capacity volume (FVC), %FVC, forced expiratory volume in the 1 s (FEV1), and %FEV1 were higher in male participants
Summary
Accumulating evidence suggests that high-density lipoprotein (HDL) cholesterol is associated with pulmonary function and pulmonary disorders. HDL cholesterol is known to reduce macrophage accumulation [3] and to transport fat molecules out of artery walls [4], thereby preventing atherosclerosis [5, 6] and cardiovascular disease [7, 8]. For this reason, HDL cholesterol as a therapeutic target for atherosclerotic disease seems attractive strategy towards preventing cardiovascular disease. In a Mendelian randomization study, genetically increased HDL cholesterol levels did not reduce the risk of myocardial infarction [11]
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