Association between glycated hemoglobin and carotid intima-media thickness in newly diagnosed type 2 diabetes patients

Abstract

Objective To examine the relationship between glycated hemoglobin (HbA1c) and carotid intima-media thickness (CIMT) in newly diagnosed 2 diabetes patients. Methods A total of 159 newly diagnosed type 2 diabetes patients visiting the Drum Tower Hospital, Nanjing, were collected from January 2013 to February 2014. All patients were divided into A group (HbA1c≤7.0%, n=44), B group (7.0% 9.0%, n=57) HbA1c, triacylglycerol (TG), total cholesterol (TC), high density lipoprotein cholesterol-C (HDL-C), low density lipoprotein cholesterol-C (LDL-C), lipoprotein AⅠ (APOAⅠ) and lipoprotein B (APOB). CIMT and the presence of carotid plaques were determined using ultrasonography. Pearson′s correlation test was performed to examine various correlations. The effect of glycaemic control on various parameters was evaluated by one-way analysis of variance. Logistic regression analysis was used for statistical analysis. Results C group demonstrated significantly higher left CIMT, right CIMT, average CIMT and maximal CIMT levels as compared to A group and B group. Logistic stepwise regression analysis indicated that the independent factors of maximal CIMT were age and HbA1c［age, odds ratio (OR)=1.103, 95% confidence interval (CI):1.038-1.173, P<0.05; HbA1c, OR=2.531, 95%CI:1.558-4.111, P<0.05］. Conclusion HbA1c was significantly associated with CIMT in newly diagnosed diabetes patients.This study indicated that HbA1c might be an independent factor of elevated maximal CIMT in newly diagnosed type 2 diabetes patients. （Chin J Lab Med,2014,37:917-920） Key words: Newly diagnosed type 2 diabetes patients; Glycated hemoglobin; Carotid intima-media thickness