Abstract
BackgroundThe association of the aldehyde dehydrogenases-2 (ALDH2) Glu504Lys polymorphism (also named Glu487Lys, or rs671) and cancers has been investigated. This meta-analysis aims to comprehensively assess the influence of this polymorphism on the overall cancer risk.MethodsEligible publications were retrieved according to inclusion/exclusion criteria and the data were analyzed using the Review Manager software (V5.2).ResultsA meta-analysis based on 51 case-control studies consisting of 16774 cases and 32060 controls was performed to evaluate the association between the ALDH2 Glu504Lys polymorphism and cancer risk. The comparison of genotypes Lys+ (Lys/Lys and Lys/Glu) with Glu/Glu yielded a significant 20% increased cancer risk (OR = 1.20, 95%CI: 1.03–1.39, P = 0.02, I2 = 92%). Subgroup analysis by cancer type indicated a significantly increased UADT cancer risk (OR = 1.39, 95%CI: 1.11–1.73, P = 0.004, I2 = 94%) in individuals with the Lys+ genotypes. Subgroup analysis by country indicated that individuals from Japan with the Lys+ genotypes had a significant 38% increased cancer risk (OR = 1.38, 95%CI: 1.12–1.71, P = 0.003, I2 = 93%).ConclusionsOur results indicated that the ALDH2 Glu504Lys polymorphism is a susceptible loci associated with overall cancers, especially esophageal cancer and among Japanese population.
Highlights
Based on available epidemiological data, alcohol ingestion is shown to be carcinogenic to humans and causally related with liver, colorectal, female breast and upper aerodigestive tract (UADT) cancers [1]
A meta-analysis based on 51 case-control studies consisting of 16774 cases and 32060 controls was performed to evaluate the association between the aldehyde dehydrogenases-2 (ALDH2) Glu504Lys polymorphism and cancer risk
Subgroup analysis by cancer type indicated a significantly increased UADT cancer risk (OR = 1.39, 95% confidence intervals (95%CI): 1.11–1.73, P = 0.004, I2 = 94%) in individuals with the Lys+ genotypes
Summary
Based on available epidemiological data, alcohol ingestion is shown to be carcinogenic to humans and causally related with liver, colorectal, female breast and upper aerodigestive tract (UADT) cancers [1]. Aldehyde dehydrogenase-2 (ALDH2) is expressed in the liver as well as gastrointestinal tract It belongs to a low-Km mitochondrial ALDH and is the second enzyme to eliminate most of the acetaldehyde generated during alcohol metabolism in vivo [4]. The exact position of the variant is 457 of NP_001191818.1 and 504 of NP_000681.2 The glutamate of this polymorphism is corresponding to Ã1 allele, and lysine corresponding to Ã2 allele. The association of the aldehyde dehydrogenases-2 (ALDH2) Glu504Lys polymorphism ( named Glu487Lys, or rs671) and cancers has been investigated. This meta-analysis aims to comprehensively assess the influence of this polymorphism on the overall cancer risk
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