Abstract
Results 1) Total of 92 children, 74(80.4%) had sufficiently catch up. 2) 69(75%) were fl/fl, 15(16.3%) were fl/d3 and 8 (8.6%) were d3/d3 the SGA groups, compared with 81%, 18%, and 1%, respectively in the Korean controls (P=0.04). 3) The highest catch up rate was seen in the fl/d3 subgroup(86.6%), the lowest in the d3/d3 subgroup (62.5%). The differences were not significant. 3)d3/d3 GHR genotype in the SGA groups is higher than in the Korean controls. 4) Fl/fl GHR genotype is higher than other published data in SGA groups.
Highlights
Association between exon-3 polymorphism of the GH Receptor(GHR) gene with catch growth in children born small for gestational age
The aim of this study was to investigate relationship between GHR exon 3 genotype and catch up growth in children fullterm born small for gestational age
DNA for the GHR exon 3 genotyping was isolated from peripheral blood lymphocytes and was analyzed by multiplex PCR
Summary
Association between exon-3 polymorphism of the GH Receptor(GHR) gene with catch growth in children born small for gestational age From 7th APPES Biennial Scientific Meeting Nusa Dua, Bali. Objective The aim of this study was to investigate relationship between GHR exon 3 genotype and catch up growth in children fullterm born small for gestational age. Methods Children were classified as SGA if birth weight was less than -2SDS.
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