Abstract
The in vitro effect of association between cadmium chloride (CdCl 2) and diphenyl diselenide (PhSe) 2 was investigated. Mouse liver, kidney and testes were used to evaluate δ-aminolevulinate dehydratase (δ-ALA-D) activity and thiobarbituric acid-reactive substances (TBARS) levels. CdCl 2 and (PhSe) 2, at different concentrations, caused an inhibition in δ-ALA-D activity of liver, kidney and testes. The inhibitory effect of (PhSe) 2 in hepatic and renal δ-ALA-D activity was attenuated by interaction of this compound with CdCl 2 at non-inhibitory concentration. Dithiothreitol (DTT), but not ZnCl 2, restored the inhibition observed in δ-ALA-D activity in all tissues. This suggests an involvement of sulfhydryl groups in δ-ALA-D inhibition. TBARS levels were increased by CdCl 2 in all tissues and (PhSe) 2 was able to abolish this increase. The results demonstrate that the association between CdCl 2 and (PhSe) 2 attenuates the toxicity of both compounds and the possible mechanisms of this protection are due to complex formation between cadmium and selenium and involves the antioxidant activity of (PhSe) 2.
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