Abstract
BackgroundAlthough chronic periodontitis has previously been reported to be linked with Alzheimer's disease (AD), the pathogenesis between the two is unclear. The purpose of this study is to analyze and screen the relevant and promising molecular markers between chronic periodontitis and Alzheimer's disease (AD).MethodsIn this paper, we analyzed three AD expression datasets and extracted differentially expressed genes (DEGs), then intersected them with chronic periodontitis genes obtained from text mining, and finally obtained integrated DEGs. We followed that by enriching the matching the matching cell signal cascade through DAVID analysis. Moreover, the MCODE of Cytoscape software was employed to uncover the protein–protein interaction (PPI) network and the matching hub gene. Finally, we verified our data using a different independent AD cohort.ResultsThe chronic periodontitis gene set acquired from text abstracting was intersected with the previously obtained three AD groups, and 12 common genes were obtained. Functional enrichment assessment uncovered 12 cross-genes, which were mainly linked to cell morphogenesis involved in neuron differentiation, leading edge membrane, and receptor ligand activity. After PPI network creation, the ten hub genes linked to AD were retrieved, consisting of SPP1, THY1, CD44, ITGB1, HSPB3, CREB1, SST, UCHL1, CCL5 and BMP7. Finally, the function terms in the new independent dataset were used to verify the previous dataset, and we found 22 GO terms and one pathway, "ECM-receptor interaction pathways", in the overlapping functional terms.ConclusionsThe establishment of the above-mentioned candidate key genes, as well as the enriched signaling cascades, provides promising molecular markers for chronic periodontitis-related AD, which may help the diagnosis and treatment of AD patients in the future.
Highlights
Chronic periodontitis has previously been reported to be linked with Alzheimer’s disease (AD), the pathogenesis between the two is unclear
Jiang et al BMC Oral Health (2021) 21:466 of serum and saliva NLRP3 in patients with chronic periodontitis + type-II diabetes mellitus (DM) is significantly higher than that of patients with simple type-II DM [4]; results indicated that periodontitis was significantly correlated with the above biomarkers
The results showed that through network analysis of GO, KEGG and protein–protein interaction (PPI), four pivot genes (ITGB1, Secreted phosphoprotein 1 (SPP1), CD44 and THY1) and two other genes of interest (CCL5 and Bone morphogenetic protein 7 (BMP7)) were screened out
Summary
Chronic periodontitis has previously been reported to be linked with Alzheimer’s disease (AD), the pathogenesis between the two is unclear. The purpose of this study is to analyze and screen the relevant and promising molecular markers between chronic periodontitis and Alzheimer’s disease (AD). Jiang et al BMC Oral Health (2021) 21:466 of serum and saliva NLRP3 in patients with chronic periodontitis + type-II diabetes mellitus (DM) is significantly higher than that of patients with simple type-II DM [4]; results indicated that periodontitis was significantly correlated with the above biomarkers. In the studies on chronic periodontitis and neurodegenerative diseases such as cognitive decline, there have been relevant reports, such as Cestari et al ’s results showing that the level of inflammatory cytokines in individuals with Alzheimer’s disease (AD) is correlated with periodontitis, it is still unclear which specific gene targets are involved [5]. As the threat of AD to the elderly becomes greater and greater, it is imperative for us to establish the etiology, as well as the molecular features of AD disease
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