Abstract
Benign prostatic hyperplasia is a commonly diagnosed disease in elderly men, but elderly men with benign prostatic hyperplasia are more likely to have a lower quality of life and depressive symptoms. This study aims to examine the association benign prostatic hyperplasia patients with suicide death relative to a control group comprising individuals without benign prostatic hyperplasia. We used the Korean National Health Insurance Service-National Sample Cohort from 2006 to 2015 comprising of 193,785 Korean adults ≥40 years old, and followed-up for suicide death during the 8.7 years period. Cox-proportional hazard model was used to estimate hazard ratios for suicide among patients with benign prostatic hyperplasia. From 2006 to 2010, a total of 32,215 people were newly diagnosed with benign prostatic hyperplasia. The suicide rate of people without benign prostatic hyperplasia was 61.6 per 100,000 person-years, whereas that of patients with benign prostatic hyperplasia was 97.3 per 100,000 person-years, 1.58 times higher than the control group (p<0.01). After adjusting for covariates, the hazard ratio for suicide among patients with benign prostatic hyperplasia was 1.47 (95% C.I. = 1.21 to 1.78; p<0.01) compared to people without benign prostatic hyperplasia. For men without mental disorders, the hazard ratio for suicide among patients with benign prostatic hyperplasia was 1.36 (95% CI = 1.05 to 1.76) compared to control group after adjusting for multiple covariates. Our study suggests that men with benign prostatic hyperplasia had a higher probability of suicide compared to men without benign prostatic hyperplasia in South Korea. This study suggests that physicians may be aware that men newly diagnosed with benign prostatic hyperplasia had high probability of suicide.
Highlights
Benign prostatic hyperplasia (BPH) is a common disease in men aged 40 years old
Previous studies have demonstrated that patients diagnosed with BPH or having lower urinary tract symptoms (LUTS) have more depressive symptoms and poorer quality of life compared to controls, the fact that this leads to suicide is rarely known based on our knowledge
Our study showed meaningful findings that patients with BPH have a higher probability of suicide compared to general population using a large sample cohort data representing South Korea, especially considering the fact that there are barely any studies show an association between BPH and probability of suicide
Summary
Benign prostatic hyperplasia (BPH) is a common disease in men aged 40 years old. It is not open for free, and researchers have to pay a certain amount for use. This database cannot be taken out freely and must be accessed using a virtual computer system. We have no special privileges in accessing the data from NHIS-NSC
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